DUSP6

Gene Name		dual specificity phosphatase 6
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Inactivation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Dorsal/ventral Pattern Formation Response To Organic Cyclic Compound Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Peptidyl-tyrosine Dephosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Response To Drug Regulation Of Endodermal Cell Fate Specification Positive Regulation Of Apoptotic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: MAPK1 MAPK3 MDFI SRPK1 TEX11 ZNF212
Entrez ID		1848
HPRD ID		04124
Ensembl ID		ENSG00000139318
Uniprot IDs		Q16828
PDB IDs		1HZM 1MKP
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Regulation Of Golgi Organization Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Early Endosome To Late Endosome Transport Activation Of MAPK Activity Regulation Of Stress-activated MAPK Cascade Developmental Process Involved In Reproduction JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of MAP Kinase Activity MAPK Cascade Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Regulation Of MAP Kinase Activity Response To Growth Hormone Response To Exogenous DsRNA Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Toll-like Receptor 10 Signaling Pathway Single Organism Reproductive Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Heat Activation Of MAPKK Activity MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Intracellular Transport Toll-like Receptor 3 Signaling Pathway Positive Regulation Of MAPK Cascade Response To DsRNA Reproductive Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Toll-like Receptor 4 Signaling Pathway Reproductive Structure Development Reproductive System Development Sensory Perception Of Pain Negative Regulation Of Binding Viral Process Positive Regulation Of Transferase Activity
Tagcloud ?		adenocarcinoma agar assays downregulated du145 dual experiments interleukin invasion knockdown lncap matrix mediator metallopeptidase metastasis numerous overexpression phosphatase pivotal plays proliferation promoted prostate remains soft specificity suppressed taken unclear