AATK and PTPN7

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		AATK	PTPN7
Description		apoptosis associated tyrosine kinase	protein tyrosine phosphatase non-receptor type 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Brain Development Neuron Apoptotic Process	MAPK Cascade Protein Dephosphorylation Signal Transduction
Pathways			Negative regulation of MAPK pathway Interleukin-37 signaling
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Basophil percentage of white cells ( 32888494) Breast cancer ( 23535733) Mean spheric corpuscular volume ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		41 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2	17 interacting genes: AATK APP CCDC57 EGFR EPHA2 ERBB3 ERBB4 GMCL1 IGF1R MAPK1 MAPK14 MAPK3 PPP1CA PRKACA PTK7 ROR2 SIRPA
Entrez ID		9625	5778
HPRD ID		05591	01480
Ensembl ID		ENSG00000181409	ENSG00000143851
Uniprot IDs		H7C175 Q6ZMQ8	B4DZD9 P35236
PDB IDs			1ZC0 2A3K 2GP0 2GPH 2HVL 2QDC 2QDM 2QDP 3D42 3D44 3O4S 3O4T 3O4U
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Protein Modification Process Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cytoplasm MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Negative Regulation Of Signaling Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Negative Regulation Of Cell Communication Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Phosphatase Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of MAPK Cascade Phosphatidylinositol Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Peptidyl-threonine Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Phospholipid Dephosphorylation Macromolecule Metabolic Process Intracellular Signaling Cassette Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Intracellular Signal Transduction ERK1 And ERK2 Cascade Manganese Ion Binding Cerebellar Cortex Formation Peptidyl-serine Dephosphorylation Phosphatidylinositol Metabolic Process Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity MAPK Cascade N-terminal Protein Myristoylation ErbB-3 Class Receptor Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Negative Regulation Of Transport Nucleoplasm	Protein Kinase Activity Kinase Activity ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Transferase Activity Nucleotide Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Animal Organ Development Regulation Of Signal Transduction Response To Epidermal Growth Factor Regulation Of Locomotion Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Glial Cell Development MAP Kinase Activity Intracellular Signaling Cassette Schwann Cell Development Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Programmed Cell Death Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Stress-activated MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Localization Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Interleukin-34-mediated Signaling Pathway Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis
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