DUSP6 and LTK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP6	LTK
Description		dual specificity phosphatase 6	leukocyte receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity
	Biological Process	MAPK Cascade Signal Transduction Response To Xenobiotic Stimulus Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Retinoic Acid
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants	Signaling by LTK
Drugs			Fostamatinib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)	High density lipoprotein cholesterol levels ( 31928498) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte percentage of white cells ( 32888494) Type 2 diabetes ( 30297969) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Interacting Genes		12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212	6 interacting genes: CBL DUSP6 MTMR14 PIK3C2B PTPN1 SHC1
Entrez ID		1848	4058
HPRD ID		04124	01052
Ensembl ID		ENSG00000139318	ENSG00000062524
Uniprot IDs		Q16828 Q53GP9	P29376
PDB IDs		1HZM 1MKP	7NX0 7NX1
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Phosphorylation Protein Autophosphorylation ATP Binding ERBB2 Signaling Pathway Protein Serine Kinase Activity Interleukin-34-mediated Signaling Pathway Protein Serine/threonine Kinase Activity Nucleotide Binding Transferase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neuroinflammatory Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Peptidyl-tyrosine Autophosphorylation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Cellular Developmental Process MAP Kinase Activity GABA Receptor Binding Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Gland Development Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Face Development Peptidyl-threonine Phosphorylation Stress-activated MAPK Cascade Cell Development	Ephrin Receptor Binding Receptor Tyrosine Kinase Binding Response To Growth Factor Response To Platelet-derived Growth Factor Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Dephosphorylation Insulin Receptor Binding Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Phosphotyrosine Residue Binding Negative Regulation Of ERK1 And ERK2 Cascade Insulin Receptor Signaling Pathway Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Response To Nutrient Levels Protein Tyrosine Phosphatase Activity Phosphate-containing Compound Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Shc-EGFR Complex Cellular Response To Hypoxia Cytosol Phosphoprotein Phosphatase Activity Dephosphorylation Phosphatidylinositol Metabolic Process Cellular Response To Decreased Oxygen Levels Response To Stress Regulation Of MAPK Cascade Cellular Response To Oxygen Levels Regulation Of Rap Protein Signal Transduction Negative Regulation Of MAPK Cascade Macroautophagy Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Insulin Receptor Recycling Positive Regulation Of Cell Proliferation In Bone Marrow Epidermal Growth Factor Binding Intracellular Signal Transduction Glycerophospholipid Biosynthetic Process Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Regulation Of Cell Proliferation In Bone Marrow Ubiquitin-dependent Endocytosis MAP Kinase Tyrosine Phosphatase Activity Lipid Kinase Activity Sorting Endosome Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?