KLK4 and SHBG

Number of citations of the paper that reports this interaction (PMID 15862967)
1

Data Source:
HPRD (two hybrid)

		KLK4	SHBG
Gene Name		kallikrein-related peptidase 4	sex hormone-binding globulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Metal Ion Binding	Androgen Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Protein Catabolic Process Amelogenesis	Primary Spermatocyte Growth
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Androgen levels ( 22936694) Protein quantitative trait loci ( 18464913) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597)
Protein-Protein Interactions		3 interactors: SERPINA3 SHBG TYRO3	62 interactors: A2M ACPP ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5A1 AZGP1 C9orf24 CD177 CECR5 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		9622	6462
HPRD ID		04793	01646
Ensembl ID		ENSG00000167749	ENSG00000129214
Uniprot IDs		Q96RU5 Q9Y5K2	B0FWH2 B4DYU0 I3L1J1 I3L2X4 P04278
PDB IDs		2BDG 2BDH 2BDI	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW
Enriched GO Terms of Interacting Partners?		Primary Spermatocyte Growth Neuron Cellular Homeostasis Spermatogenesis Male Gamete Generation Vagina Development Maintenance Of Gastrointestinal Epithelium Gamete Generation Natural Killer Cell Differentiation Epithelial Structure Maintenance Developmental Process Involved In Reproduction Female Genitalia Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Toll-like Receptor Signaling Pathway Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Apoptotic Cell Clearance Negative Regulation Of Innate Immune Response Platelet Aggregation Protein Kinase B Signaling Acute-phase Response Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Reproduction Genitalia Development Single Organism Reproductive Process Natural Killer Cell Activation Reproductive Process	Platelet Activation Extracellular Matrix Disassembly Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Zinc Ion Endocytosis Vesicle-mediated Transport Response To Wounding Transport Endosomal Transport Cell Activation Response To Zinc Ion Cell Projection Organization Immune System Process MRNA Transcription From RNA Polymerase II Promoter Glucose Metabolic Process MRNA Transcription Neuron Projection Development Movement Of Cell Or Subcellular Component Cellular Response To Cadmium Ion Regulation Of Water Loss Via Skin Formation Of Translation Preinitiation Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Morphogenesis Involved In Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Hexose Metabolic Process Neuron Development Extracellular Matrix Organization Viral Process Cytoplasmic Sequestering Of Protein Regulation Of Defense Response To Virus By Virus Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axon Development Antigen Processing And Presentation Of Peptide Antigen Locomotion Negative Regulation Of Growth Monosaccharide Metabolic Process Sperm Entry Negative Regulation Of T Cell Migration Contractile Actin Filament Bundle Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Positive Regulation Of Late Endosome To Lysosome Transport Sorbitol Catabolic Process L-xylitol Metabolic Process L-xylitol Catabolic Process Fructose Biosynthetic Process
Tagcloud ?		ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger ltf protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Difference) ?		ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger ltf protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Intersection) ?