KLK4 and SERPINA3

Number of citations of the paper that reports this interaction (PMID 11735417)
16

Data Source:
HPRD (in vitro)

		KLK4	SERPINA3
Gene Name		kallikrein-related peptidase 4	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Metal Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Protein Catabolic Process Amelogenesis	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Body mass index ( 23669352)
Protein-Protein Interactions		3 interactors: SERPINA3 SHBG TYRO3	25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		9622	12
HPRD ID		04793	00120
Ensembl ID		ENSG00000167749	ENSG00000196136
Uniprot IDs		Q96RU5 Q9Y5K2	G3V5I3 P01011
PDB IDs		2BDG 2BDH 2BDI	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA
Enriched GO Terms of Interacting Partners?		Primary Spermatocyte Growth Neuron Cellular Homeostasis Spermatogenesis Male Gamete Generation Vagina Development Maintenance Of Gastrointestinal Epithelium Gamete Generation Natural Killer Cell Differentiation Epithelial Structure Maintenance Developmental Process Involved In Reproduction Female Genitalia Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Toll-like Receptor Signaling Pathway Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Apoptotic Cell Clearance Negative Regulation Of Innate Immune Response Platelet Aggregation Protein Kinase B Signaling Acute-phase Response Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Reproduction Genitalia Development Single Organism Reproductive Process Natural Killer Cell Activation Reproductive Process	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response
Tagcloud ?		ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger ltf protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Difference) ?		ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger ltf protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Intersection) ?