KLK4 and TYRO3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KLK4	TYRO3
Gene Name		kallikrein-related peptidase 4	TYRO3 protein tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Metal Ion Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity
	Biological Process	Proteolysis Extracellular Matrix Disassembly Protein Catabolic Process Amelogenesis	Natural Killer Cell Differentiation Cell Adhesion Signal Transduction Spermatogenesis Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Signal Transduction By Phosphorylation Platelet Activation Secretion By Cell Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: SERPINA3 SHBG TYRO3	20 interactors: A2M APOE AXL FYN GAS6 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LNX1 MDFI PIK3R1 PROS1 SRC YES1
Entrez ID		9622	7301
HPRD ID		04793	02641
Ensembl ID		ENSG00000167749	ENSG00000092445
Uniprot IDs		Q96RU5 Q9Y5K2	Q06418
PDB IDs		2BDG 2BDH 2BDI	1RHF
Enriched GO Terms of Interacting Partners?		Primary Spermatocyte Growth Neuron Cellular Homeostasis Spermatogenesis Male Gamete Generation Vagina Development Maintenance Of Gastrointestinal Epithelium Gamete Generation Natural Killer Cell Differentiation Epithelial Structure Maintenance Developmental Process Involved In Reproduction Female Genitalia Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Toll-like Receptor Signaling Pathway Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Apoptotic Cell Clearance Negative Regulation Of Innate Immune Response Platelet Aggregation Protein Kinase B Signaling Acute-phase Response Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Reproduction Genitalia Development Single Organism Reproductive Process Natural Killer Cell Activation Reproductive Process	Platelet Activation Blood Coagulation Response To Wounding Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Regulation Of Cell Activation Phagocytosis Regulation Of Immune System Process Positive Regulation Of Cell Activation Vesicle-mediated Transport Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Endocytosis Cell Activation Regulation Of Lymphocyte Activation T Cell Costimulation Innate Immune Response Response To Stress Intracellular Signal Transduction Cell Migration Immune Response Regulation Of Immune Response Cell Motility Negative Regulation Of Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune System Process Negative Regulation Of Programmed Cell Death Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Response To Growth Factor Negative Regulation Of Dendritic Cell Apoptotic Process Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Locomotion Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization To Nucleus Response To Peptide Hormone Defense Response Negative Regulation Of Neuron Death
Tagcloud ?		ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger ltf protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated	anticoagulant ark axl brt called chinese composed ectopically eyk fc fused g1 gas6 hamster immunoglobulin ligand maximal member mer native ovary rse sky specifically stimulates structurally subfamily tyrosine ufo
Tagcloud (Difference) ?		ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger ltf protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated	anticoagulant ark axl brt called chinese composed ectopically eyk fc fused g1 gas6 hamster immunoglobulin ligand maximal member mer native ovary rse sky specifically stimulates structurally subfamily tyrosine ufo
Tagcloud (Intersection) ?