TBC1D8

Description		TBC1 domain family member 8
Image		No pdb structure
GO Annotations	Cellular Component	Membrane
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	System Process Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Cilium Assembly
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive decline rate in late mild cognitive impairment ( 26252872) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Granulocyte count ( 27863252) Heel bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Osteoporosis-related phenotypes ( 20548944) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: SPP1 TRAF1 TRAF4
Entrez ID		11138
HPRD ID		06752
Ensembl ID		ENSG00000204634
Uniprot IDs		J3KQ40 O95759
PDB IDs
Enriched GO Terms of Interacting Partners?		Thioesterase Binding Tumor Necrosis Factor Receptor Binding Signaling Adaptor Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Androgen Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Bone Resorption Response To Macrophage Colony-stimulating Factor Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Respiratory Tube Development Hormone Catabolic Process Regulation Of Collateral Sprouting Decidualization Regulation Of Neuron Projection Regeneration Perinuclear Region Of Cytoplasm Response To Vitamin D Regulation Of Axon Regeneration Small Molecule Binding Androgen Metabolic Process Steroid Catabolic Process Respiratory Gaseous Exchange By Respiratory System WW Domain Binding Extracellular Matrix Binding Regulation Of Bone Resorption
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