RNF7 and UBE2L3

Number of citations of the paper that reports this interaction (PubMedID 30587576)
50

Data Source:
BioGRID (pull down)

		RNF7	UBE2L3
Description		ring finger protein 7	ubiquitin conjugating enzyme E2 L3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Copper Ion Binding Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding	Nucleotide Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Reelin-mediated Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Phosphocreatine Biosynthetic Process Defense Response To Virus Response To Redox State Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Protein K11-linked Ubiquitination Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Regulation Of Neuron Migration	Protein Polyubiquitination Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Cell Cycle Phase Transition Positive Regulation Of DNA-templated Transcription Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation	PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling Regulation of necroptotic cell death Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hepatitis C induced liver fibrosis ( 22841784) Pelvic organ prolapse (moderate/severe) ( 26545240)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Celiac disease ( 20190752 30572963 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 24097068 20686565 25961943) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepatitis B ( 24162738) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 20139978 29403010 28017375 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Psoriasis ( 23143594) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 21408207 23273568 26502338 27399966 28714469 19838193 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Total cholesterol levels ( 30275531) Ulcerative colitis ( 28067908)
Interacting Genes		43 interacting genes: APOBEC3F APOBEC3G ARIH2 ASB11 BTRC CASP7 CBFB CDC34 CHFR CREBBP CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL5 CYCS ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBA3 UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2L3 UBE2M UBE2Q1 USP40	113 interacting genes: ANKIB1 AREL1 ARIH1 ARIH2 ATXN3 BRAP BRCA1 CBL CBLB CBLC CCNB1IP1 CDC42 CDKN1B CUL5 CUL9 DTX3 FBXO2 FOS HACE1 HECTD1 HECTD2 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC3 HERC4 HERC6 HSPA4 HUWE1 IRF2BP1 ITCH LIG4 LTN1 MAPK6 MDM2 MEX3A MEX3C MID1 MKRN2 MKRN3 MUL1 MYCBP2 NEDD4 NEDD4L NFKBIA NR3C1 OTUD3 PIAS1 PIAS2 PJA1 POLR2A PRKN PTEN RBCK1 RBX1 RC3H1 RELA RNF103 RNF111 RNF113B RNF114 RNF125 RNF14 RNF144A RNF144B RNF150 RNF168 RNF170 RNF182 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF31 RNF7 RTF2 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TP53 TRAF6 TRAF7 TRIM13 TRIM21 TRIM23 TRIM25 TRIM28 TRIM31 TRIM39 TRIM55 TRIP12 UBA1 UBA5 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR4 UBR5 VPS11 WWP1 WWP2 XIAP
Entrez ID		9616	7332
HPRD ID		04840	04762
Ensembl ID		ENSG00000114125	ENSG00000185651
Uniprot IDs		Q9UBF6	P68036
PDB IDs		2ECL 7ONI	1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13 6XXU 7B5L 7B5N 7OIK 7V8F 8EAZ 8EB0
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cullin-RING Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity Nucleus Cell Cycle Phase Transition Cul5-RING Ubiquitin Ligase Complex Protein K11-linked Ubiquitination Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition NEDD8 Transferase Activity Cytosol Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Virus Defense Response To Virus Intracellular Signal Transduction Protein K63-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway NEDD8 Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin-like Protein Transferase Activity Protein Destabilization	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Zinc Ion Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Cytoplasm Negative Regulation Of Signal Transduction Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K63-linked Ubiquitination Positive Regulation Of Catabolic Process Intracellular Signal Transduction Protein Monoubiquitination Cellular Response To Stress Regulation Of Signal Transduction Response To Stress Cytosol Intracellular Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
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