RNF7 and CHFR

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		RNF7	CHFR
Description		ring finger protein 7	checkpoint with forkhead and ring finger domains
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex	Nucleus PML Body
	Molecular Function	Copper Ion Binding Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Reelin-mediated Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Phosphocreatine Biosynthetic Process Defense Response To Virus Response To Redox State Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Protein K11-linked Ubiquitination Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Regulation Of Neuron Migration	Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Meiotic Spindle Checkpoint Signaling Mitotic G2/M Transition Checkpoint Cell Division
Pathways		Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hepatitis C induced liver fibrosis ( 22841784) Pelvic organ prolapse (moderate/severe) ( 26545240)	Cognitive function ( 24684796) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373)
Interacting Genes		43 interacting genes: APOBEC3F APOBEC3G ARIH2 ASB11 BTRC CASP7 CBFB CDC34 CHFR CREBBP CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL5 CYCS ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBA3 UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2L3 UBE2M UBE2Q1 USP40	30 interacting genes: AURKA BRD4 CBLC EEF1G GABBR1 GRB10 GRB14 HDAC1 HDAC2 ITGAE PML RNF125 RNF7 SIRT1 SMARCA4 SMARCB1 SMARCD1 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2L1 UBE2N UBE2W WDR47
Entrez ID		9616	55743
HPRD ID		04840	05552
Ensembl ID		ENSG00000114125	ENSG00000072609
Uniprot IDs		Q9UBF6	Q96EP1
PDB IDs		2ECL 7ONI	1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cullin-RING Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity Nucleus Cell Cycle Phase Transition Cul5-RING Ubiquitin Ligase Complex Protein K11-linked Ubiquitination Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition NEDD8 Transferase Activity Cytosol Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Virus Defense Response To Virus Intracellular Signal Transduction Protein K63-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway NEDD8 Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin-like Protein Transferase Activity Protein Destabilization	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein Polyubiquitination Macromolecule Catabolic Process Protein K11-linked Ubiquitination Proteolysis Transferase Activity Protein Monoubiquitination Protein K48-linked Ubiquitination Protein Metabolic Process P53 Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Signal Transduction Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Stem Cell Population Maintenance Host-mediated Perturbation Of Viral Transcription Regulation Of Double-strand Break Repair Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Nucleosomal DNA Binding Positive Regulation Of Double-strand Break Repair Chromatin Remodeling Protein Lysine Deacetylase Activity ATP Binding NpBAF Complex Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Activity RSC-type Complex Regulation Of DNA Repair NBAF Complex Negative Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Repair Histone Deacetylase Activity Nucleosome Disassembly
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