ETS2 and DMXL2

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		ETS2	DMXL2
Name		ETS proto-oncogene 2, transcription factor	Dmx like 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane	Extracellular Space Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle RAVE Complex Synapse Neuronal Dense Core Vesicle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Small GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation	Vacuolar Acidification
Pathways		Oncogene Induced Senescence	None
GWAS		Adult body size ( 32376654 ) Body mass index ( 25673413 ) Body size at age 10 ( 32376654 ) C-reactive protein levels ( 30388399 ) Central corneal thickness ( 32528159 ) Eye morphology ( 29921221 ) Fibrinogen levels ( 28107422 ) Finger osteoarthritis severity (hand Klsum) ( 33055079 ) Fractures ( 30158200 ) Intraocular pressure ( 29617998 ) Non-small cell lung cancer (survival) ( 21079520 ) Periodontitis (Mean PAL) ( 24024966 ) Schizophrenia ( 30285260 ) Serum alkaline phosphatase levels ( 33547301 ) TPE interval (response to exercise) ( 32386560 )	BMI (adjusted for smoking behaviour) ( 28443625 ) Body mass index ( 25673413 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) C-reactive protein levels ( 30388399 ) Intelligence (MTAG) ( 29326435 ) Triglyceride levels ( 32203549 )
Interacting Genes		37 interacting genes: CDK10 CLU COP1 CREBBP DAD1 DMXL2 EGLN2 EP300 ERG ETS1 FOCAD FOS GABRD GATA3 GTF3C4 JUN NCOR1 NDRG1 NDUFB5 NR3C1 POU5F1 PPME1 RPL15 SERPINE2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 TERF2IP TTC3 UBC USP7 ZBTB44 ZFYVE9 ZMYND11	5 interacting genes: AKTIP ETS2 MTNR1B PCNT RAB3A
Entrez ID		2114	23312
HPRD ID		01263	10188
Ensembl ID		ENSG00000157557	ENSG00000104093
Uniprot IDs		P15036	H0YLM8 Q8TDJ6
PDB IDs		4BQA 4MHV	Not available
GO Terms Enriched among Interactors		Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Chromatin Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding DNA Binding Myeloid Cell Differentiation Chromatin Organization Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K27 Acetyltransferase Activity Positive Regulation Of Leukocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Pro-T Cell Differentiation Mononuclear Cell Differentiation Host-mediated Activation Of Viral Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Activation Response To Stress Myeloid Leukocyte Activation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell-cell Adhesion DNA-binding Transcription Factor Activity Transcription Regulator Complex Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Leukocyte Differentiation	Ectodermal Cell Fate Commitment Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Constitutive Secretory Pathway Synaptic Vesicle Maturation Regulation Of Presynaptic Dense Core Granule Exocytosis Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Regulation Of Plasma Membrane Repair Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Acrosomal Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Maintenance Of Presynaptic Active Zone Structure Clathrin-sculpted Monoamine Transport Vesicle Membrane Sensory Perception Of Touch FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Primitive Streak Formation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Nuclear Glucocorticoid Receptor Binding Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Vesicle Organization Synaptic Vesicle Clustering Regulation Of Short-term Neuronal Synaptic Plasticity Presynaptic Active Zone Organization Positive Regulation Of Protein Binding HOPS Complex Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Plasma Membrane Organization Myosin V Binding Synaptic Vesicle Recycling Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Ubiquitin-like Protein Transferase Activity Positive Regulation Of Circadian Rhythm Regulation Of Protein Transport GTP-dependent Protein Binding