GABBR2 and GADD45G

		GABBR2	GADD45G
Description		gamma-aminobutyric acid type B receptor subunit 2	growth arrest and DNA damage inducible gamma
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Synapse Postsynaptic Membrane GABA Receptor Complex G Protein-coupled GABA Receptor Complex	Nucleus Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, GABAergic Neuron-glial Cell Signaling	Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil Sodium oxybate
Diseases
GWAS		Autism spectrum disorder ( 34069769) Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectory ( 27980656) tricyclic pyrone compound response (IC50) ( 33610756)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 26561523 28107422) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638) Triglyceride levels ( 32154731 32203549)
Interacting Genes		10 interacting genes: ATF4 ATF5 DRD2 GABBR1 GLP1R HTR1A KCTD12 NSF SH3GL3 TAMALIN	74 interacting genes: ACTN1 AFAP1L1 APP ARPC5L BEND7 BLOC1S2 CCNB1 CDK1 CDK11A CDKN1A CEP57L1 CFAP44 CNOT9 CRIP2 DCTN2 DDAH2 DDIT4L EEF1A1 EEF1G EIF3G ENKD1 ESR1 EZH2 FAM156A FAM156B GADD45B GADD45GIP1 GDF9 GRAMD4 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN NMB PCNA PDE4DIP PDIA4 PHAX PIAS4 PLAGL2 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RASSF10 RBM48 RCN1 RDH13 REL RRP7A RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579 ZNF664 ZNF763
Entrez ID		9568	10912
HPRD ID		09552	05383
Ensembl ID		ENSG00000136928	ENSG00000130222
Uniprot IDs		H9NIL8 O75899	O95257
PDB IDs		4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2	2WAL 3FFM
Enriched GO Terms of Interacting Partners?		Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Dopamine Secretion Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catecholamine Secretion GABA-ergic Synapse Regulation Of Transport Circadian Rhythm RNA Polymerase II Transcription Regulator Complex Presynaptic Membrane Regulation Of Receptor-mediated Endocytosis Regulation Of Dopamine Secretion G Protein-coupled Receptor Activity Ionotropic Glutamate Receptor Binding Negative Regulation Of Transport Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Dendritic Shaft Response To Nicotine Regulation Of Signaling Negative Regulation Of Blood Pressure Synapse Glucagon-like Peptide 1 Receptor Activity Regulation Of Hormone Levels Circadian Regulation Of Gene Expression Cell-cell Signaling ATF1-ATF4 Transcription Factor Complex Rhythmic Process CHOP-ATF4 Complex Regulation Of Hormone Secretion Regulation Of Blood Circulation G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Vesicle-mediated Transport Regulation Of Secretion Glutamatergic Synapse Regulation Of Secretion By Cell G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Gamma-aminobutyric Acid Secretion Sphinganine Biosynthetic Process Regulation Of Fat Cell Apoptotic Process Sphinganine Metabolic Process	Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Regulation Of MiRNA Transcription Protein Binding Regulation Of MiRNA Metabolic Process Nuclear Steroid Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin B1-CDK1 Complex PCNA-p21 Complex Peroxisome Proliferator Activated Receptor Signaling Pathway Microtubule Cytoskeleton Organization Involved In Mitosis RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Gene Expression Sequence-specific DNA Binding Cyclin-dependent Protein Kinase Holoenzyme Complex Hormone-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Transcription Coactivator Binding Regulation Of Cell Population Proliferation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport DNA Binding Domain Binding Negative Regulation Of Lipid Storage Regulation Of Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centrosome Rhythmic Process Response To Estradiol Retinoic Acid Receptor Signaling Pathway Regulation Of Circadian Rhythm Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Molecular Function Activator Activity Positive Regulation Of Lipoprotein Transport Establishment Of Organelle Localization Organelle Localization Chromatin Negative Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Chromatin Binding Positive Regulation Of RNA Metabolic Process Regeneration Positive Regulation Of Chromosome Segregation
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