GABBR2 and ATF5

Number of citations of the paper that reports this interaction (PubMedID 11087824)
41

Data Source:
HPRD (two hybrid)

		GABBR2	ATF5
Description		gamma-aminobutyric acid type B receptor subunit 2	activating transcription factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Synapse Postsynaptic Membrane GABA Receptor Complex G Protein-coupled GABA Receptor Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Cytoskeleton RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Tubulin Binding Kinase Binding Sequence-specific DNA Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, GABAergic Neuron-glial Cell Signaling	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Negative Regulation Of Cell Population Proliferation Post-embryonic Development Regulation Of Gene Expression Olfactory Bulb Interneuron Differentiation Olfactory Bulb Interneuron Development Cerebellar Granule Cell Precursor Proliferation Olfactory Lobe Development Multicellular Organism Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centrosome Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Response of EIF2AK1 (HRI) to heme deficiency Mitochondrial unfolded protein response (UPRmt) Mitochondrial unfolded protein response (UPRmt)
Drugs		Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil Sodium oxybate	Pseudoephedrine
Diseases
GWAS		Autism spectrum disorder ( 34069769) Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectory ( 27980656) tricyclic pyrone compound response (IC50) ( 33610756)
Interacting Genes		10 interacting genes: ATF4 ATF5 DRD2 GABBR1 GLP1R HTR1A KCTD12 NSF SH3GL3 TAMALIN	18 interacting genes: ATXN1 CCDC6 CCND3 CDC34 CEBPA CEBPE CEBPG DISC1 EIF2B1 EP300 FBXO7 GABBR1 GABBR2 GIT2 GPS2 KEAP1 SYCE1L TTR
Entrez ID		9568	22809
HPRD ID		09552	05906
Ensembl ID		ENSG00000136928	ENSG00000169136
Uniprot IDs		H9NIL8 O75899	Q9Y2D1
PDB IDs		4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2
Enriched GO Terms of Interacting Partners?		Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Dopamine Secretion Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catecholamine Secretion GABA-ergic Synapse Regulation Of Transport Circadian Rhythm RNA Polymerase II Transcription Regulator Complex Presynaptic Membrane Regulation Of Receptor-mediated Endocytosis Regulation Of Dopamine Secretion G Protein-coupled Receptor Activity Ionotropic Glutamate Receptor Binding Negative Regulation Of Transport Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Dendritic Shaft Response To Nicotine Regulation Of Signaling Negative Regulation Of Blood Pressure Synapse Glucagon-like Peptide 1 Receptor Activity Regulation Of Hormone Levels Circadian Regulation Of Gene Expression Cell-cell Signaling ATF1-ATF4 Transcription Factor Complex Rhythmic Process CHOP-ATF4 Complex Regulation Of Hormone Secretion Regulation Of Blood Circulation G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Vesicle-mediated Transport Regulation Of Secretion Glutamatergic Synapse Regulation Of Secretion By Cell G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Gamma-aminobutyric Acid Secretion Sphinganine Biosynthetic Process Regulation Of Fat Cell Apoptotic Process Sphinganine Metabolic Process	Mononuclear Cell Differentiation G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Leukocyte Differentiation GABA Receptor Complex Integrated Stress Response Signaling Neuron-glial Cell Signaling GABA Receptor Activity Identical Protein Binding STAT Family Protein Binding DNA-templated Transcription Lymphocyte Activation Protein-containing Complex Myeloid Cell Differentiation Lymphocyte Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Leukocyte Activation Signal Transduction B Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Gamma-aminobutyric Acid Signaling Pathway Protein Heterodimerization Activity Granulocyte Differentiation Protein-containing Complex Binding Cell Activation Synaptic Transmission, GABAergic Nucleoplasm Regulation Of Cell Differentiation Macrophage Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding B Cell Activation Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite
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