ATP6V1G1 and MAGEA6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ATP6V1G1	MAGEA6
Description		ATPase H+ transporting V1 subunit G1	MAGE family member A6
Image			No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Synaptic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex	Nucleus
	Molecular Function	Protein Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Protein Binding Histone Deacetylase Binding
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid
Diseases
GWAS		Bone mineral density (hip) and age at menarche ( 26312577) Bone mineral density (spine) and age at menarche ( 26312577)	Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		14 interacting genes: AP2B1 APP ATP6V1E1 ATP6V1E2 BCL2L11 GOLGA2 GOLGA6L9 GORASP2 LDOC1 LHX3 MAGEA6 NTAQ1 PNMA1 UBQLN2	75 interacting genes: ACOT7 ACTN3 AKAP9 ANKRD26P1 APOA4 ARFIP1 ATOSA ATP6V1G1 ATPAF2 BCL7B BET1 BFSP2 BOLA3 C1orf216 CAMTA2 CBFA2T2 CCDC146 CCDC185 CCDC187 CCDC24 COL4A6 CTF1 DLGAP3 DLGAP4 DNTTIP1 ELMOD3 EXOC5 FRMPD1 GADD45GIP1 GCSH GFOD1 HAUS1 HLA-DRB4 HNRNPM IQUB KIF27 KLHL38 LCORL LIN37 LIN52 LSM2 MCM7 MCRS1 MED21 MID2 MIPOL1 MORN3 MSGN1 NCK2 NOSTRIN PCBD2 PDE4D PRKAA1 RASSF10 RASSF4 RCOR3 REX1BD RPL37A RUSC1 S100A14 S100A9 SH2D4A SMARCD1 SNAP47 SNX4 SON STAMBPL1 STX5 TRIM26 TRIM28 TSPYL6 TULP3 TXNDC9 XRCC4 ZNF76
Entrez ID		9550	4105
HPRD ID		06294	02168
Ensembl ID		ENSG00000136888	ENSG00000197172
Uniprot IDs		O75348	P43360
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Proton-transporting Two-sector ATPase Complex, Catalytic Domain Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Autophagy Regulation Of Response To Endoplasmic Reticulum Stress Proton-transporting ATPase Activity, Rotational Mechanism Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Macroautophagy Cis-Golgi Network BIM-BCL-2 Complex Response To Endoplasmic Reticulum Stress BIM-BCL-xl Complex Protein-N-terminal Glutamine Amidohydrolase Activity	Protein Binding SNARE Complex Suppression Of Viral Release By Host
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