ATP6V1G1 and AP2B1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATP6V1G1	AP2B1
Gene Name		ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	adaptor-related protein complex 2, beta 1 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Extracellular Vesicular Exosome	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Hydrogen-exporting ATPase Activity, Phosphorylative Mechanism ATPase Binding	Signal Sequence Binding Protein Binding Protein Transporter Activity Clathrin Binding Clathrin Adaptor Activity
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Transferrin Transport Interaction With Host Transmembrane Transport Phagosome Maturation Hydrogen Ion Transmembrane Transport	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis
Pathways		Phagosomal maturation (early endosomal stage) Iron uptake and transport Latent infection of Homo sapiens with Mycobacterium tuberculosis Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor	Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		8 interactors: AP2B1 APP ATP6V1E1 ATP6V1E2 BCL2L11 GOLGA2 LDOC1 MAGEA6	44 interactors: ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP6V1G1 BUB1 BUB1B CLINT1 CLTC DHX58 FAM46C GTF2I HIP1 ITSN1 KIAA0408 KPNA2 LDLRAP1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 RAPGEF3 RIBC2 SLC25A6 SMAD4 SMURF1 SNAP91 TERF2IP TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 XRCC6BP1
Entrez ID		9550	163
HPRD ID		06294	03015
Ensembl ID			ENSG00000006125
Uniprot IDs		O75348	K7EJT8 P63010 Q96EL6
PDB IDs			1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7
Enriched GO Terms of Interacting Partners?		Interaction With Host Transition Metal Ion Homeostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Transferrin Transport Phagosome Maturation Enzyme Linked Receptor Protein Signaling Pathway ATP Hydrolysis Coupled Proton Transport Cellular Metal Ion Homeostasis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Iron Ion Transport Cellular Cation Homeostasis Cellular Iron Ion Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Homeostatic Process Synaptic Growth At Neuromuscular Junction Ion Homeostasis Iron Ion Homeostasis Collateral Sprouting In Absence Of Injury Positive Regulation Of Peptidase Activity Regulation Of Protein Binding Insulin Receptor Signaling Pathway Cellular Homeostasis Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process By Virus Cell Surface Receptor Signaling Pathway Hydrogen Ion Transmembrane Transport Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Axon Choice Point Recognition Thymocyte Apoptotic Process B Cell Apoptotic Process Post-embryonic Organ Morphogenesis Chemical Homeostasis Proton Transport Neurotrophin Signaling Pathway Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Cellular Process Regulating Host Cell Cycle In Response To Virus Neuron Remodeling Positive Regulation Of Protein Homooligomerization Regulation Of Binding Positive Regulation Of Cell Cycle	Protein Localization Regulation Of Defense Response To Virus By Virus Endocytosis Viral Process Cellular Localization Protein Transport Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Localization In Cell Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Transport Clathrin Coat Assembly Membrane Organization Receptor-mediated Endocytosis Cellular Protein Localization Organelle Organization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Post-Golgi Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Apoptotic Process Clathrin-mediated Endocytosis Response To Growth Factor Negative Regulation Of Chromosome Segregation Programmed Cell Death Cell Cycle Process Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Cell Development Cell Death Death Regulation Of Signaling Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Chromosome Organization Regulation Of Signal Transduction Cellular Protein Complex Assembly Pathway-restricted SMAD Protein Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Cellular Response To Organic Substance Negative Regulation Of Protein Catabolic Process Cell Activation Cell Cycle Mitotic Cell Cycle Process
Tagcloud ?			17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Difference) ?			17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Intersection) ?