ATP6V1G1 and ATP6V1E1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical, cross-linking study, cross-linking study, cross-linking study)
HPRD (two hybrid)

		ATP6V1G1	ATP6V1E1
Description		ATPase H+ transporting V1 subunit G1	ATPase H+ transporting V1 subunit E1
Image
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Synaptic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytoplasm Lysosomal Membrane Endosome Cytosol Plasma Membrane Microvillus Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting Two-sector ATPase Complex, Catalytic Domain Synapse Extracellular Exosome
	Molecular Function	Protein Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Monoatomic Ion Transport Regulation Of Macroautophagy Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid	Tiludronic acid
Diseases
GWAS		Bone mineral density (hip) and age at menarche ( 26312577) Bone mineral density (spine) and age at menarche ( 26312577)
Interacting Genes		14 interacting genes: AP2B1 APP ATP6V1E1 ATP6V1E2 BCL2L11 GOLGA2 GOLGA6L9 GORASP2 LDOC1 LHX3 MAGEA6 NTAQ1 PNMA1 UBQLN2	14 interacting genes: ALDOA ALDOB ALDOC APP ATP6V0E1 ATP6V1G1 ATP6V1G2 ATP6V1H HSPB2 MESD NHERF1 SOS1 TRAF6 XRCC6
Entrez ID		9550	529
HPRD ID		06294	00163
Ensembl ID		ENSG00000136888	ENSG00000131100
Uniprot IDs		O75348	P36543 Q53Y06
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF	6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Proton-transporting Two-sector ATPase Complex, Catalytic Domain Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Autophagy Regulation Of Response To Endoplasmic Reticulum Stress Proton-transporting ATPase Activity, Rotational Mechanism Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Macroautophagy Cis-Golgi Network BIM-BCL-2 Complex Response To Endoplasmic Reticulum Stress BIM-BCL-xl Complex Protein-N-terminal Glutamine Amidohydrolase Activity	Fructose-bisphosphate Aldolase Activity Proton-transporting ATPase Activity, Rotational Mechanism Fructose 1,6-bisphosphate Metabolic Process Homeostatic Process Vacuolar Proton-transporting V-type ATPase, V1 Domain Fructose Metabolic Process Extrinsic Component Of Synaptic Vesicle Membrane Cellular Homeostasis Proton-transporting V-type ATPase Complex ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Lyase Activity Glycolytic Process Growth Factor Receptor Binding Proton Transmembrane Transport ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Fructose Binding Ribonucleoside Diphosphate Catabolic Process Regulation Of Macroautophagy Pyruvate Metabolic Process Cytoskeletal Protein Binding Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Intracellular Chemical Homeostasis Vacuolar Proton-transporting V-type ATPase Complex Regulation Of Phosphorus Metabolic Process Nucleotide Catabolic Process Synaptic Vesicle Lumen Acidification Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Secretory Granule Lumen Ficolin-1-rich Granule Lumen Nucleoside Phosphate Catabolic Process Fc-epsilon Receptor Signaling Pathway ATP Hydrolysis Activity Regulation Of Autophagy Low-density Lipoprotein Particle Receptor Binding Monoatomic Cation Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis ATP Metabolic Process Hexose Metabolic Process Organophosphate Catabolic Process Clathrin-coated Vesicle Membrane Cytosol Monosaccharide Metabolic Process Vacuolar Acidification
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