RSPH14 and ALS2CL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RSPH14	ALS2CL
Description		radial spoke head 14 homolog	ALS2 C-terminal like
Image			No pdb structure
GO Annotations	Cellular Component	Radial Spoke Cytoplasm Cytoskeleton Cilium Motile Cilium Cell Projection	Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process		Endosomal Transport
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Serum parathyroid hormone levels ( 27927781)
Interacting Genes		40 interacting genes: ABI2 AGAP1 ALS2CL AP1M1 AP2M1 BPIFA1 CCDC102B CDR2 CNTROB COG6 EPS8 FHL3 GABPB1 GOLGA2 JUP KASH5 KIFC3 KRT15 KRT31 KRT40 KRT75 KRT76 LZTS1 MNS1 PIBF1 POLR1C REL RPH3AL RSPH3 SEPTIN12 SMAD4 TCF4 TRAF2 TRIM27 TRIM50 TRIM69 TRIM7 VPS9D1 ZNF474 ZNF629	7 interacting genes: EEF1AKMT3 RAB22A RAB31 RAB5A RAB5C RSPH14 SAXO4
Entrez ID		27156	259173
HPRD ID		16136	10643
Ensembl ID		ENSG00000100218	ENSG00000178038
Uniprot IDs		Q9UHP6	Q60I27
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Cytoskeleton Organization Supramolecular Fiber Organization Cytoskeleton Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Organelle Organization Structural Molecule Activity Protein Binding Identical Protein Binding Zonula Adherens Sebaceous Gland Development Clathrin Adaptor Complex Centrosome Separation Positive Regulation Of Actin Nucleation Small GTPase Binding Innate Immune Response Epithelial Cell-cell Adhesion Clathrin Adaptor Activity	GDP Binding Early Endosome Endomembrane System GTPase Activity Phagocytic Vesicle Phagocytic Vesicle Membrane Plasma Membrane To Endosome Transport GTP Binding Endocytosis Regulation Of Vesicle Size Intracellular Protein Transport Import Into Cell Early Endosome Membrane Endosome Receptor Internalization Endocytic Vesicle G Protein Activity Protein Transport Endosome Organization Vesicle-mediated Transport Intracellular Transport Melanosome Ruffle Cell Projection Establishment Of Protein Localization Regulation Of Vesicle-mediated Transport Protein Localization To Early Endosome Early Phagosome Membrane Cytoplasmic Side Of Early Endosome Membrane Cellular Localization Late Endosome Establishment Of Localization In Cell Receptor-mediated Endocytosis Nucleotide Binding Amyloid-beta Clearance By Transcytosis Intracellular Protein Localization Motile Cilium Cytoplasmic Vesicle Regulation Of Cellular Component Size Regulation Of Endosome Size Endosomal Transport Phagosome Maturation Early Phagosome Radial Spoke Actin Cytoskeleton Endosome Membrane Protein Localization To Endosome Positive Regulation Of Phagocytosis, Engulfment Synaptic Vesicle Recycling Somatodendritic Compartment
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