FXR2 and CAMK2D

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FXR2	CAMK2D
Gene Name		fragile X mental retardation, autosomal homolog 2	calcium/calmodulin-dependent protein kinase II delta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Polysome Membrane Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding MRNA Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Inhibitor Activity Titin Binding Protein Homodimerization Activity Ion Channel Binding Nitric-oxide Synthase Binding
	Biological Process	Negative Regulation Of Translation	Regulation Of Cell Growth Response To Hypoxia Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Synaptic Transmission Regulation Of Heart Contraction Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Potassium Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Heat Positive Regulation Of Rac Protein Signal Transduction Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Oligomerization Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Localization Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cellular Response To Heat Regulation Of Histone Deacetylase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		IgM levels ( 23118916) Sex hormone-binding globulin levels ( 22675492)	White matter integrity (interaction) ( 23218918)
Protein-Protein Interactions		90 interactors: AMOTL2 AP1M1 AP2M1 ARL6IP1 BAZ2B BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2D CBS CCDC33 CCDC85B CDKL3 CEP44 CEP55 COIL CYFIP1 CYFIP2 DPPA2 EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GKAP1 HMBOX1 HNRNPC KCNRG KCTD4 KIAA1217 KIF1A KRT20 KXD1 LASP1 LCMT1 LCP2 LDOC1 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MRPL43 NCK2 NDN NECAB2 NIF3L1 NME1 NONO NT5C2 PAF1 PAICS PCBD1 PIM1 POM121 PRAM1 PSME3 PTS RABAC1 RALYL RBBP8 RBMX RBPMS RPIA RTN3 RTN4 SCEL SNAP23 SRPK2 SSSCA1 SYT6 SYTL4 TBC1D22B THAP1 TNNT1 TRAF2 TRIM23 TRIM29 TRIM37 TSC22D4 YES1 ZBTB22 ZBTB8A ZMAT2 ZNF451 ZSCAN1	27 interactors: ACTN2 ARL2BP BANP CAMK2B CD5 CREM DNAL4 EPHA10 FAM171B FKBP1B FNDC3B FXR2 GRIN2B HDAC4 HNMT IFNGR2 MOAP1 MRPL11 RPS18 RPS4X SPATA24 SRPK1 STAT1 TNPO2 TTC5 VIM WASF3
Entrez ID		9513	817
HPRD ID		05629	09653
Ensembl ID		ENSG00000129245	ENSG00000145349
Uniprot IDs		P51116	D6R938 E9PF82 Q13557
PDB IDs		3H8Z	2VN9 2W2C 2WEL 3GP2
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Process Cellular Process Negative Regulation Of Centriole Replication Macromolecule Biosynthetic Process Developmental Cell Growth Protein Homooligomerization Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Cellular Macromolecule Biosynthetic Process Protein Autoubiquitination Protein Oligomerization Histone Acetylation Vesicle-mediated Transport Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Centriole Replication Histone H4 Acetylation Internal Protein Amino Acid Acetylation Pteridine-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Negative Regulation Of Gene Expression Protein Acetylation DNA Recombination Histone H2A Acetylation Cellular Metabolic Process Neuron Projection Extension Negative Regulation Of Centrosome Duplication Cell Growth Negative Regulation Of Cell Growth Histone Modification	Signaling Cell Communication Muscle System Process Protein Localization To Organelle Signal Transduction Viral Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cell Differentiation Interferon-gamma-mediated Signaling Pathway Multicellular Organismal Development Response To Stress Developmental Process Regulation Of Cellular Process Translational Termination Cellular Response To Interferon-gamma Actin-myosin Filament Sliding Muscle Filament Sliding Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Response To Cytokine Response To Interferon-gamma Translational Elongation Negative Regulation Of Transporter Activity Cellular Protein Complex Disassembly Actin-mediated Cell Contraction Negative Regulation Of Macrophage Fusion Inhibitory G-protein Coupled Receptor Phosphorylation Negative Regulation Of Ion Transmembrane Transport Protein Complex Disassembly Gene Expression Muscle Contraction Negative Regulation Of Transmembrane Transport Regulation Of Cell Development Nervous System Development Establishment Of Protein Localization To Membrane Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Defense Response Actin Filament-based Movement Cellular Protein Localization Cellular Localization Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Activation Of Meiosis Involved In Egg Activation Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Sequestering Of Calcium Ion Protein Localization Regulation Of Cardiac Muscle Contraction
Tagcloud ?		17p13 adipocytes array cgh disability duplication dysmorphic encodes encompassing facial fingers fissures glut4 hyperpigmentation intellectual mandible nlgn2 nostrils obesity p13 palpebral proposita recognizable referred seizures slc2a4 slender tp53 upturned	abcc8 acacb cacna1a cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt tll1 trpc5 trpv3
Tagcloud (Difference) ?		17p13 adipocytes array cgh disability duplication dysmorphic encodes encompassing facial fingers fissures glut4 hyperpigmentation intellectual mandible nlgn2 nostrils obesity p13 palpebral proposita recognizable referred seizures slc2a4 slender tp53 upturned	abcc8 acacb cacna1a cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt tll1 trpc5 trpv3
Tagcloud (Intersection) ?