CAMK2D and CREM

Number of citations of the paper that reports this interaction (PMID 8404858)
24

Data Source:
HPRD (in vitro, in vivo)

		CAMK2D	CREM
Gene Name		calcium/calmodulin-dependent protein kinase II delta	cAMP responsive element modulator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Inhibitor Activity Titin Binding Protein Homodimerization Activity Ion Channel Binding Nitric-oxide Synthase Binding	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Regulation Of Cell Growth Response To Hypoxia Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Synaptic Transmission Regulation Of Heart Contraction Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Potassium Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Heat Positive Regulation Of Rac Protein Signal Transduction Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Oligomerization Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Localization Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cellular Response To Heat Regulation Of Histone Deacetylase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Glycosphingolipid Metabolic Process Signal Transduction Multicellular Organismal Development Spermatogenesis Cell Differentiation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To CAMP
Pathways		Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		White matter integrity (interaction) ( 23218918)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		27 interactors: ACTN2 ARL2BP BANP CAMK2B CD5 CREM DNAL4 EPHA10 FAM171B FKBP1B FNDC3B FXR2 GRIN2B HDAC4 HNMT IFNGR2 MOAP1 MRPL11 RPS18 RPS4X SPATA24 SRPK1 STAT1 TNPO2 TTC5 VIM WASF3	29 interactors: ATF1 ATXN1 CAMK2D CAMK2G CASP8AP2 CD34 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 EMP3 FHL5 GSK3A GSK3B HDAC1 KCNIP3 MAPK3 PIAS3 PRKACA PRKCA SP100 SPI1 TAF4 TBP UBE2I
Entrez ID		817	1390
HPRD ID		09653	00444
Ensembl ID		ENSG00000145349	ENSG00000095794
Uniprot IDs		D6R938 E9PF82 Q13557	Q03060
PDB IDs		2VN9 2W2C 2WEL 3GP2
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Muscle System Process Protein Localization To Organelle Signal Transduction Viral Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cell Differentiation Interferon-gamma-mediated Signaling Pathway Multicellular Organismal Development Response To Stress Developmental Process Regulation Of Cellular Process Translational Termination Cellular Response To Interferon-gamma Actin-myosin Filament Sliding Muscle Filament Sliding Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Response To Cytokine Response To Interferon-gamma Translational Elongation Negative Regulation Of Transporter Activity Cellular Protein Complex Disassembly Actin-mediated Cell Contraction Negative Regulation Of Macrophage Fusion Inhibitory G-protein Coupled Receptor Phosphorylation Negative Regulation Of Ion Transmembrane Transport Protein Complex Disassembly Gene Expression Muscle Contraction Negative Regulation Of Transmembrane Transport Regulation Of Cell Development Nervous System Development Establishment Of Protein Localization To Membrane Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Defense Response Actin Filament-based Movement Cellular Protein Localization Cellular Localization Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Activation Of Meiosis Involved In Egg Activation Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Sequestering Of Calcium Ion Protein Localization Regulation Of Cardiac Muscle Contraction	Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Response To Heat Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Cardiac Muscle Hypertrophy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transcription, DNA-templated Response To Growth Factor Cell Death Death Cellular Protein Modification Process Regulation Of Metabolic Process Cell Cycle RNA Biosynthetic Process Regulation Of Cellular Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Gene Expression Peptidyl-serine Phosphorylation Hypermethylation Of CpG Island Peptidyl-amino Acid Modification Nucleobase-containing Compound Metabolic Process Apoptotic Process Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Programmed Cell Death Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Macromolecule Biosynthetic Process Cellular Response To Heat Heterocycle Metabolic Process
Tagcloud ?		abcc8 acacb cacna1a cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt tll1 trpc5 trpv3	27mer abp activin artefact artefactual basally bluescript bouin crna cystatin digoxigenin distinguishable inhibin ix leptotene promotor propria protamine pyronin rbs riboprobes seminiferous sgp spermatocytes sulphated t7 trichloroacetic tubules viii
Tagcloud (Difference) ?		abcc8 acacb cacna1a cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt tll1 trpc5 trpv3	27mer abp activin artefact artefactual basally bluescript bouin crna cystatin digoxigenin distinguishable inhibin ix leptotene promotor propria protamine pyronin rbs riboprobes seminiferous sgp spermatocytes sulphated t7 trichloroacetic tubules viii
Tagcloud (Intersection) ?