CAMK2D and EPHA10

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CAMK2D	EPHA10
Gene Name		calcium/calmodulin-dependent protein kinase II delta	EPH receptor A10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Inhibitor Activity Titin Binding Protein Homodimerization Activity Ion Channel Binding Nitric-oxide Synthase Binding	Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Cell Growth Response To Hypoxia Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Synaptic Transmission Regulation Of Heart Contraction Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Potassium Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Heat Positive Regulation Of Rac Protein Signal Transduction Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Oligomerization Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Localization Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cellular Response To Heat Regulation Of Histone Deacetylase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Axon Guidance Biological_process Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway
Pathways		Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		White matter integrity (interaction) ( 23218918)	Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		27 interactors: ACTN2 ARL2BP BANP CAMK2B CD5 CREM DNAL4 EPHA10 FAM171B FKBP1B FNDC3B FXR2 GRIN2B HDAC4 HNMT IFNGR2 MOAP1 MRPL11 RPS18 RPS4X SPATA24 SRPK1 STAT1 TNPO2 TTC5 VIM WASF3	4 interactors: BANP CAMK2D FHL3 TFCP2
Entrez ID		817	284656
HPRD ID		09653	08163
Ensembl ID		ENSG00000145349	ENSG00000183317
Uniprot IDs		D6R938 E9PF82 Q13557	Q4G0R4 Q5JZY3 Q8N289
PDB IDs		2VN9 2W2C 2WEL 3GP2
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Muscle System Process Protein Localization To Organelle Signal Transduction Viral Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cell Differentiation Interferon-gamma-mediated Signaling Pathway Multicellular Organismal Development Response To Stress Developmental Process Regulation Of Cellular Process Translational Termination Cellular Response To Interferon-gamma Actin-myosin Filament Sliding Muscle Filament Sliding Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Response To Cytokine Response To Interferon-gamma Translational Elongation Negative Regulation Of Transporter Activity Cellular Protein Complex Disassembly Actin-mediated Cell Contraction Negative Regulation Of Macrophage Fusion Inhibitory G-protein Coupled Receptor Phosphorylation Negative Regulation Of Ion Transmembrane Transport Protein Complex Disassembly Gene Expression Muscle Contraction Negative Regulation Of Transmembrane Transport Regulation Of Cell Development Nervous System Development Establishment Of Protein Localization To Membrane Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Defense Response Actin Filament-based Movement Cellular Protein Localization Cellular Localization Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Activation Of Meiosis Involved In Egg Activation Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Sequestering Of Calcium Ion Protein Localization Regulation Of Cardiac Muscle Contraction	Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Cardiac Muscle Cell Contraction Regulation Of Generation Of L-type Calcium Current Regulation Of Histone Deacetylase Activity Positive Regulation Of Rac Protein Signal Transduction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Cellular Potassium Ion Homeostasis Regulation Of Relaxation Of Muscle Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Sodium Ion Transport Regulation Of Cell Communication By Electrical Coupling Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Muscle Structure Development Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Cardiac Muscle Hypertrophy Relaxation Of Muscle Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Actin Filament-based Process Cardiac Muscle Hypertrophy Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Muscle Hypertrophy Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Response To Heat Regulation Of The Force Of Heart Contraction Cardiac Muscle Tissue Growth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Histone Deacetylation Regulation Of Membrane Depolarization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Rac Protein Signal Transduction Negative Regulation Of Transporter Activity Regulation Of Smooth Muscle Cell Migration Actin-mediated Cell Contraction Regulation Of Cardiac Muscle Cell Contraction Regulation Of G2/M Transition Of Mitotic Cell Cycle Cardiac Conduction Peptidyl-threonine Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Ion Transmembrane Transport Cellular Response To Calcium Ion Regulation Of Protein Deacetylation
Tagcloud ?		abcc8 acacb cacna1a cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt tll1 trpc5 trpv3
Tagcloud (Difference) ?		abcc8 acacb cacna1a cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt tll1 trpc5 trpv3
Tagcloud (Intersection) ?