CAMK2D and WASF3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CAMK2D	WASF3
Description		calcium/calmodulin dependent protein kinase II delta	WASP family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Neuron Projection	Cytoplasm Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome Glial Cell Projection Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Sodium Channel Inhibitor Activity Titin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Serine Kinase Activity	Actin Binding Protein Binding Protein Kinase A Regulatory Subunit Binding Arp2/3 Complex Binding
	Biological Process	Regulation Of Cell Growth Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Regulation Of Heart Contraction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Neuronal Synaptic Plasticity Relaxation Of Cardiac Muscle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Localization Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Protein Localization To Plasma Membrane	Cytoskeleton Organization Regulation Of Cell Shape Oligodendrocyte Development Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Myelination Protein-containing Complex Assembly Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Fostamatinib
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Chronic lymphocytic leukemia ( 24292274 28165464) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 28552196) Non-small cell lung cancer (survival) ( 25145502) P wave duration ( 28794112) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Small vessel stroke (CCS and TOAST classification) ( 32047268) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560) White matter integrity (bipolar disorder risk interaction) ( 23218918)	Hallux valgus ( 32131869) Left-handedness ( 32989287) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Sporadic pituitary adenoma ( 26029870) Systolic blood pressure ( 30224653)
Interacting Genes		30 interacting genes: ACTN2 ARL2BP BANP CAMK2B CD5 CREM EPHA10 ERCC8 FAM171B FKBP1B FNDC3B GRIN2B HNMT IFNGR2 MOAP1 MRPL11 RNF4 RPS18 RPS4X SMARCB1 SPATA24 SRPK1 STAT1 TNPO2 TNPO3 TTC5 UBC UBE2I VIM WASF3	12 interacting genes: ABI2 ACTB ACTR3 BYSL CAMK2D CKS1B EGFR KANK2 KIFC3 PIK3R1 PIK3R2 RASAL3
Entrez ID		817	10810
HPRD ID		09653	05458
Ensembl ID		ENSG00000145349	ENSG00000132970
Uniprot IDs		A0A8V8TN60 A0A8V8TN65 A0A8V8TN88 A0A8V8TNA1 A0A8V8TNA7 A0A8V8TPJ8 A0A8V8TPY4 A0A994J516 A0A994J5B0 D6R938 E9PBG7 E9PF82 Q13557	Q5T8P4 Q9UPY6
PDB IDs		2VN9 2W2C 2WEL 3GP2 5VLO 6AYW 7ZRP 7ZRQ 8USO
Enriched GO Terms of Interacting Partners?		Cytoplasm Nuclear Matrix	Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Membrane Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Adherens Junction Organization Regulation Of Lamellipodium Organization 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cellular Localization Regulation Of Protein Localization Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Motility Protein Phosphatase Binding Adherens Junction Assembly Regulation Of Cellular Component Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Focal Adhesion Regulation Of Protein Localization To Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Intracellular Signaling Cassette Cell-cell Junction Organization Regulation Of Cell Cycle G1/S Phase Transition Adherens Junction Lamellipodium Regulation Of Mitotic Cell Cycle Cell-cell Junction Positive Regulation Of Protein Import Into Nucleus Regulation Of Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Phosphotyrosine Residue Binding Regulation Of Cell Projection Assembly Positive Regulation Of Norepinephrine Uptake Identical Protein Binding Cellular Response To Cytochalasin B Multivesicular Body, Internal Vesicle Lumen GTPase Activator Activity Brush Border Regulation Of Protein Import Into Nucleus Regulation Of Organelle Organization Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Norepinephrine Uptake Positive Regulation Of Protein Localization To Cell Periphery
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