SCARB1 and SNAP23

		SCARB1	SNAP23
Description		scavenger receptor class B member 1	synaptosome associated protein 23
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Caveola Cell Surface Membrane Endocytic Vesicle Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Plasma Membrane Adherens Junction Focal Adhesion Cilium Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Specific Granule Membrane Specific Granule Azurophil Granule Neuron Projection Synapse Extracellular Exosome Tertiary Granule Membrane Presynapse
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Virus Receptor Activity Phosphatidylserine Binding Lipopolysaccharide Immune Receptor Activity Scavenger Receptor Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding High-density Lipoprotein Particle Receptor Activity	SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Endothelial Cell Proliferation Cholesterol Catabolic Process Lipid Transport Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Cholesterol Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Vitamin Transmembrane Transport Wound Healing Vasodilation Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Regulation Of Phagocytosis High Density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cholesterol Import Intestinal Lipid Absorption Positive Regulation Of Sphingolipid Mediated Signaling Pathway	Histamine Secretion By Mast Cell Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Targeting Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Fusion
Pathways			ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs		Phosphatidyl serine
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 33020668 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Facial skin colour (CIELAB index b* value) ( 34648798) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol ( 20686565 30275531 24097068 25961943) HDL cholesterol levels ( 28334899 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817 31217584 29403010) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) LDL cholesterol levels ( 32203549) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857 23118302) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862) Renal cell carcinoma ( 21131975) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Serum metabolite levels ( 33031748) Total bilirubin levels ( 29403010) Total cholesterol levels ( 33339817 29403010) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Vitamin E levels ( 21729881) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 31043756)
Interacting Genes		9 interacting genes: APOA1 APOA2 APOE GPR35 KRTAP10-9 KRTAP5-9 LTB4R2 PDZK1 PEX5	32 interacting genes: ABI2 ABI3 CFTR FXR2 ITSN1 KIF5B MATR3 NAPA NAPB PRKCA SCAMP1 SCAMP2 SCGN SNAPIN SNTG1 STX11 STX12 STX1A STX1B STX3 STX4 STX5 STX6 STXBP2 STXBP5 TLK1 VAMP1 VAMP2 VAMP3 VAMP7 VAMP8 WASH2P
Entrez ID		949	8773
HPRD ID		03024	03962
Ensembl ID		ENSG00000073060	ENSG00000092531
Uniprot IDs		A0A7P0Z4E3 B3KW46 B7ZKQ9 Q8WTV0	A8K287 O00161
PDB IDs			1NHL 3ZUS
Enriched GO Terms of Interacting Partners?		Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipoprotein Biosynthetic Process Protein Oxidation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein-containing Complex Assembly Cellular Response To Amyloid-beta Regulation Of Intestinal Cholesterol Absorption Spherical High-density Lipoprotein Particle Lipoprotein Particle Binding Response To Amyloid-beta Regulation Of Cholesterol Transport Protein-containing Complex Organization Cholesterol Transport Regulation Of Intestinal Lipid Absorption Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction Sterol Transport Regulation Of Intestinal Absorption Phospholipid Transport Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Cholesterol Homeostasis Sterol Homeostasis Low-density Lipoprotein Particle Remodeling Endocytic Vesicle Lumen Negative Regulation Of Cholesterol Transport Cholesterol Metabolic Process	SNARE Complex SNAP Receptor Activity Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Organelle Fusion SNARE Binding Exocytosis Organelle Localization By Membrane Tethering Membrane Docking Vesicle Docking Protein Transport Establishment Of Protein Localization Vesicle-mediated Transport Secretion By Cell Vesicle Organization Secretion Membrane Organization Establishment Of Localization In Cell Intracellular Protein Localization SNARE Complex Assembly Syntaxin Binding Organelle Localization Intracellular Protein Transport Regulation Of Exocytosis Cellular Localization Intracellular Transport Regulation Of Synaptic Vesicle Priming Regulation Of Vesicle-mediated Transport Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Secretion By Cell Regulated Exocytosis Calcium-ion Regulated Exocytosis Endomembrane System Regulation Of Secretion Zymogen Granule Membrane Phagocytic Vesicle Positive Regulation Of Exocytosis Neutrophil Degranulation Regulation Of Histamine Secretion By Mast Cell Vesicle-mediated Transport In Synapse Neuron Projection Recycling Endosome Membrane Secretory Granule Regulation Of Hormone Secretion Golgi Vesicle Transport Positive Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Synaptic Vesicle Exocytosis Synaptic Vesicle Membrane
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