SCARB1 and POLE

		SCARB1	POLE
Description		scavenger receptor class B member 1	DNA polymerase epsilon, catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Caveola Cell Surface Membrane Endocytic Vesicle Membrane Extracellular Exosome	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Virus Receptor Activity Phosphatidylserine Binding Lipopolysaccharide Immune Receptor Activity Scavenger Receptor Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding High-density Lipoprotein Particle Receptor Activity	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Endothelial Cell Proliferation Cholesterol Catabolic Process Lipid Transport Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Cholesterol Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Vitamin Transmembrane Transport Wound Healing Vasodilation Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Regulation Of Phagocytosis High Density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cholesterol Import Intestinal Lipid Absorption Positive Regulation Of Sphingolipid Mediated Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication Leading Strand Elongation DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response DNA Replication Proofreading Embryonic Organ Development DNA Biosynthetic Process
Pathways			Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Phosphatidyl serine	Cladribine
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 33020668 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Facial skin colour (CIELAB index b* value) ( 34648798) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol ( 20686565 30275531 24097068 25961943) HDL cholesterol levels ( 28334899 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817 31217584 29403010) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) LDL cholesterol levels ( 32203549) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857 23118302) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862) Renal cell carcinoma ( 21131975) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Serum metabolite levels ( 33031748) Total bilirubin levels ( 29403010) Total cholesterol levels ( 33339817 29403010) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Vitamin E levels ( 21729881) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		9 interacting genes: APOA1 APOA2 APOE GPR35 KRTAP10-9 KRTAP5-9 LTB4R2 PDZK1 PEX5	13 interacting genes: ABHD16A CFTR CLSPN GINS4 MDM2 PCNA POLA1 POLD4 POLE4 RAD17 TOPBP1 WHR1 XRCC5
Entrez ID		949	5426
HPRD ID		03024	07177
Ensembl ID		ENSG00000073060	ENSG00000177084
Uniprot IDs		A0A7P0Z4E3 B3KW46 B7ZKQ9 Q8WTV0	Q07864
PDB IDs			5VBN 7PFO 7PLO 9B8S 9B8T 9F6D 9F6E 9F6F 9F6I 9F6J 9F6K 9F6L
Enriched GO Terms of Interacting Partners?		Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipoprotein Biosynthetic Process Protein Oxidation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein-containing Complex Assembly Cellular Response To Amyloid-beta Regulation Of Intestinal Cholesterol Absorption Spherical High-density Lipoprotein Particle Lipoprotein Particle Binding Response To Amyloid-beta Regulation Of Cholesterol Transport Protein-containing Complex Organization Cholesterol Transport Regulation Of Intestinal Lipid Absorption Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction Sterol Transport Regulation Of Intestinal Absorption Phospholipid Transport Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Cholesterol Homeostasis Sterol Homeostasis Low-density Lipoprotein Particle Remodeling Endocytic Vesicle Lumen Negative Regulation Of Cholesterol Transport Cholesterol Metabolic Process	DNA Metabolic Process DNA Repair Response To Stress DNA Damage Response Cellular Response To Stress DNA Biosynthetic Process Mitotic DNA Replication Checkpoint Signaling DNA-templated DNA Replication DNA Replication DNA Replication Checkpoint Signaling DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process Leading Strand Elongation DNA Synthesis Involved In DNA Repair Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage Male Germ Cell Nucleus Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Strand Elongation Involved In DNA Replication Double-strand Break Repair Protein-containing Complex Chromatin-protein Adaptor Activity DNA Damage Checkpoint Signaling Response To Lipid DNA Strand Elongation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Cell Cycle G2/M Phase Transition Nucleoplasm Protein Localization To Site Of Double-strand Break DNA Replication Initiation Cellular Response To Gamma Radiation Recycling Endosome Regulation Of Mitotic Cell Cycle Phase Transition Recombinational Repair Response To Hormone Response To Ionizing Radiation Chromosome Organization Protein-containing Complex Binding Protein Localization To Organelle Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?