SCARB1 and DENR

		SCARB1	DENR
Description		scavenger receptor class B member 1	density regulated re-initiation and release factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Caveola Cell Surface Membrane Endocytic Vesicle Membrane Extracellular Exosome	Cytoplasm
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Virus Receptor Activity Phosphatidylserine Binding Lipopolysaccharide Immune Receptor Activity Scavenger Receptor Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding High-density Lipoprotein Particle Receptor Activity	Translation Initiation Factor Activity Protein Binding
	Biological Process	Endothelial Cell Proliferation Cholesterol Catabolic Process Lipid Transport Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Cholesterol Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Vitamin Transmembrane Transport Wound Healing Vasodilation Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Regulation Of Phagocytosis High Density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cholesterol Import Intestinal Lipid Absorption Positive Regulation Of Sphingolipid Mediated Signaling Pathway	Formation Of Translation Preinitiation Complex Cytoplasmic Translational Initiation Translation Reinitiation Translation Translational Initiation Ribosome Disassembly IRES-dependent Viral Translational Initiation
Pathways
Drugs		Phosphatidyl serine
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 33020668 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Facial skin colour (CIELAB index b* value) ( 34648798) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol ( 20686565 30275531 24097068 25961943) HDL cholesterol levels ( 28334899 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817 31217584 29403010) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) LDL cholesterol levels ( 32203549) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857 23118302) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862) Renal cell carcinoma ( 21131975) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Serum metabolite levels ( 33031748) Total bilirubin levels ( 29403010) Total cholesterol levels ( 33339817 29403010) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Vitamin E levels ( 21729881) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Apolipoprotein A1 levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)
Interacting Genes		9 interacting genes: APOA1 APOA2 APOE GPR35 KRTAP10-9 KRTAP5-9 LTB4R2 PDZK1 PEX5	3 interacting genes: MCTS1 NELFB UBC
Entrez ID		949	8562
HPRD ID		03024	05182
Ensembl ID		ENSG00000073060	ENSG00000139726
Uniprot IDs		A0A7P0Z4E3 B3KW46 B7ZKQ9 Q8WTV0	O43583
PDB IDs			5ONS 5VYC 6MS4 6VPQ 6VPR
Enriched GO Terms of Interacting Partners?		Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipoprotein Biosynthetic Process Protein Oxidation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein-containing Complex Assembly Cellular Response To Amyloid-beta Regulation Of Intestinal Cholesterol Absorption Spherical High-density Lipoprotein Particle Lipoprotein Particle Binding Response To Amyloid-beta Regulation Of Cholesterol Transport Protein-containing Complex Organization Cholesterol Transport Regulation Of Intestinal Lipid Absorption Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction Sterol Transport Regulation Of Intestinal Absorption Phospholipid Transport Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Cholesterol Homeostasis Sterol Homeostasis Low-density Lipoprotein Particle Remodeling Endocytic Vesicle Lumen Negative Regulation Of Cholesterol Transport Cholesterol Metabolic Process	Endocytic Vesicle Membrane Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity High Density Lipoprotein Particle Mediated Signaling Regulation Of Sphingolipid Mediated Signaling Pathway Lipopolysaccharide Transport Cholesterol Catabolic Process Recognition Of Apoptotic Cell Lipopolysaccharide Immune Receptor Activity Positive Regulation Of Cholesterol Storage Positive Regulation Of Nitric Oxide Mediated Signal Transduction Cholesterol Import Detection Of Lipopolysaccharide Regulation Of Phospholipid Catabolic Process Apolipoprotein A-I Binding High-density Lipoprotein Particle Clearance Regulation Of Phosphatidylcholine Catabolic Process NELF Complex Translation Reinitiation Formation Of Translation Preinitiation Complex Detection Of Molecule Of Bacterial Origin Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Nitric Oxide Mediated Signal Transduction High-density Lipoprotein Particle Binding Intestinal Lipid Absorption Phagocytosis, Recognition RNA Binding RNA Cap Binding IRES-dependent Viral Translational Initiation Adhesion Of Symbiont To Host 1-phosphatidylinositol Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Low-density Lipoprotein Particle Clearance Reverse Cholesterol Transport Vitamin Transmembrane Transport Protein Tag Activity Regulation Of Triglyceride Biosynthetic Process High-density Lipoprotein Particle Remodeling Ribosomal Small Subunit Binding Positive Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Steroid Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Scavenger Receptor Activity Negative Regulation Of Stem Cell Differentiation Negative Regulation Of DNA-templated Transcription, Elongation Plasma Lipoprotein Particle Clearance Intestinal Absorption
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