SNAP23 and NAPA

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		SNAP23	NAPA
Gene Name		synaptosomal-associated protein, 23kDa	N-ethylmaleimide-sensitive factor attachment protein, alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion SNARE Complex Specific Granule Azurophil Granule Mast Cell Granule Neuron Projection Synapse Extracellular Vesicular Exosome	Vacuolar Membrane Cytosol Membrane SNARE Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Vesicular Exosome
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin Binding	Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding
	Biological Process	Histamine Secretion By Mast Cell Post-Golgi Vesicle-mediated Transport Vesicle Targeting Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Membrane Organization Membrane Fusion	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Brain Development Regulation Of Synaptic Vesicle Priming Neuron Differentiation Synaptic Transmission, Glutamatergic SNARE Complex Disassembly Apical Protein Localization Membrane Organization Membrane Fusion
Pathways		Translocation of GLUT4 to the plasma membrane trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ABI2 ABI3 CFTR FXR2 ITSN1 KIF5B MATR3 NAPA NAPB PRKCA SCAMP1 SCAMP2 SCGN SNAPIN SNTG1 STX11 STX12 STX1A STX1B STX2 STX3 STX4 STX5 STX6 STXBP2 STXBP5 TLK1 VAMP1 VAMP2 VAMP3 VAMP5 VAMP7 VAMP8 WASH2P	17 interactors: APP BNIP1 GNA12 GOSR1 GOSR2 NSF RTN4 SNAP23 SNAP25 STX12 STX1A STX4 STX5 STX7 STX8 TRPC3 VAMP8
Entrez ID		8773	8775
HPRD ID		03962	04447
Ensembl ID		ENSG00000092531	ENSG00000105402
Uniprot IDs		A8K287 O00161	P54920
PDB IDs		1NHL 3ZUS
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle Organization Vesicle-mediated Transport Establishment Of Localization In Cell Exocytosis Cellular Localization Protein Transport Membrane Organization Establishment Of Protein Localization Intracellular Transport Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Docking Membrane Docking Secretion Protein Localization Neurotransmitter Secretion Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Synaptic Vesicle Exocytosis Neurotransmitter Transport Synaptic Vesicle Transport Golgi Vesicle Transport Transport Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Localization SNARE Complex Assembly Regulation Of Exocytosis Establishment Of Organelle Localization Organelle Organization Regulation Of Cellular Localization Cell-cell Signaling Organelle Localization Synaptic Transmission Regulation Of Secretion Regulation Of Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Positive Regulation Of Synaptic Transmission Regulation Of Synaptic Vesicle Priming Positive Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Positive Regulation Of Transport Neutrophil Degranulation Regulation Of Cellular Component Organization Golgi To Plasma Membrane Transport Regulation Of Synaptic Transmission	Membrane Fusion Organelle Fusion Vesicle Fusion Vesicle Organization Membrane Organization Vesicle-mediated Transport Vesicle Docking Membrane Docking Establishment Of Localization In Cell Intracellular Transport Synaptic Vesicle Fusion To Presynaptic Membrane Cellular Localization Protein Transport Golgi Vesicle Transport Establishment Of Protein Localization Exocytosis Post-Golgi Vesicle-mediated Transport Transport Protein Localization Secretion By Cell Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Exocytosis Intracellular Protein Transport Organelle Organization Secretion Regulation Of Cellular Localization Neurotransmitter Secretion Synaptic Vesicle Transport Cellular Protein Localization Regulation Of Cellular Component Organization Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Neurotransmitter Transport Intra-Golgi Vesicle-mediated Transport Organelle Localization Platelet Activation Positive Regulation Of Exocytosis Establishment Of Vesicle Localization Regulation Of Protein Localization Endosomal Transport Vesicle Localization Retrograde Transport, Endosome To Golgi Synaptic Vesicle Docking Vesicle Fusion With Golgi Apparatus SNARE Complex Assembly Synaptic Vesicle Priming Regulation Of Hormone Secretion Regulation Of Body Fluid Levels ER To Golgi Vesicle-mediated Transport Synaptic Transmission
Tagcloud ?		apical brevin brevins cellubrevin clostridial codistributed cryosections exocytosis exocytotic immunogold insensitive maleimide nem neurotoxin neurotoxins nsf nts proteolyze snare snares syntaxin tent tetanus ti ultrathin vamp vesicle	account activate alter beta cat construct contains cotransfected delta demonstrating element half independence inducing neuroblastoma phenylacetate promoting ra rar rare re reporter retinoic sodium sv synergize synergy upregulating vector
Tagcloud (Difference) ?		apical brevin brevins cellubrevin clostridial codistributed cryosections exocytosis exocytotic immunogold insensitive maleimide nem neurotoxin neurotoxins nsf nts proteolyze snare snares syntaxin tent tetanus ti ultrathin vamp vesicle	account activate alter beta cat construct contains cotransfected delta demonstrating element half independence inducing neuroblastoma phenylacetate promoting ra rar rare re reporter retinoic sodium sv synergize synergy upregulating vector
Tagcloud (Intersection) ?