ROCK2 and STAU1

Number of citations of the paper that reports this interaction (PMID 15121898)
40

Data Source:
HPRD (in vitro)

		ROCK2	STAU1
Gene Name		Rho-associated, coiled-coil containing protein kinase 2	staufen double-stranded RNA binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol Plasma Membrane Spindle Pole Centrosome Cytoplasmic Ribonucleoprotein Granule	Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Microtubule Associated Complex Cytoplasmic Stress Granule Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Structural Molecule Activity Protein Binding ATP Binding Rho GTPase Binding Poly(A) RNA Binding Metal Ion Binding	Double-stranded RNA Binding Protein Binding Protein Phosphatase 1 Binding Poly(A) RNA Binding
	Biological Process	Cytokinesis Neural Tube Closure Protein Phosphorylation Smooth Muscle Contraction Rho Protein Signal Transduction Axon Guidance Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Centrosome Duplication Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Regulation Of Circadian Rhythm Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Rhythmic Process Dendrite Morphogenesis Centrosome Duplication Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Intracellular MRNA Localization Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MAGEC1 PPP1R12A STAU1	39 interactors: APP CASC3 CDC42 CSNK2B DHX9 DYNC1I1 FMR1 GLRX3 HNRNPU INA IQGAP1 KIF2B LONRF1 MAP1B MAPT MYH1 NCBP1 NCL NXT1 PABPC1 PABPN1 PPP1CA PPP1CC RAC1 RASA1 ROCK2 RPL28 RPL6 RPL7A RPLP0 RPS6 SPP1 SRPK1 TAX1BP3 TUBB TUBB4A UBE2D3 UPF1 ZMAT3
Entrez ID		9475	6780
HPRD ID		04922	03422
Ensembl ID		ENSG00000134318	ENSG00000124214
Uniprot IDs		O75116	B3KRE0 O95793 Q6PJX3
PDB IDs		4L6Q	4DKK
Enriched GO Terms of Interacting Partners?		Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation By Virus Of Viral Protein Levels In Host Cell Intracellular MRNA Localization Positive Regulation Of Viral Genome Replication Regulation Of Phosphoprotein Phosphatase Activity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Intracellular Transport Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Localization RNA Transport Cytoskeleton-dependent Intracellular Transport RNA Localization Viral Process Establishment Of Localization In Cell MRNA Processing Viral Transcription SRP-dependent Cotranslational Protein Targeting To Membrane Cellular Protein Complex Disassembly Cotranslational Protein Targeting To Membrane Protein Targeting To ER Viral Life Cycle Neuron Projection Morphogenesis Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Catabolic Process Protein Complex Disassembly RNA Splicing Cytoplasmic Transport MRNA Transport Axonogenesis Organelle Transport Along Microtubule Protein Localization To Endoplasmic Reticulum Translational Initiation Microtubule-based Transport Movement Of Cell Or Subcellular Component Microtubule-based Process Axon Development RNA Processing Translational Termination Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Regulation Of Translation Cell Projection Morphogenesis Protein Targeting To Membrane RNA Export From Nucleus Cell Part Morphogenesis Translational Elongation MRNA 3'-end Processing Enzyme Linked Receptor Protein Signaling Pathway Microtubule-based Movement Developmental Cell Growth
Tagcloud ?		arthritis autoimmunity balance box collagen diminished disrupted forkhead gammat instrumental kd025 man orphan p3 pharmacological proinflammatory promoters regulates regulatory restore rheumatoid rho rock1 secrete simultaneously stat5 subsets suppressive th17	activators anaphase apc arrested asynchronous cdc20 cdh1 code consistently cyclosome e3 fluctuates hct116 impairs ligase messenger mitosis mitotic mrnas participates precedes prometaphase ribonucleic rnas transit u2os underscored
Tagcloud (Difference) ?		arthritis autoimmunity balance box collagen diminished disrupted forkhead gammat instrumental kd025 man orphan p3 pharmacological proinflammatory promoters regulates regulatory restore rheumatoid rho rock1 secrete simultaneously stat5 subsets suppressive th17	activators anaphase apc arrested asynchronous cdc20 cdh1 code consistently cyclosome e3 fluctuates hct116 impairs ligase messenger mitosis mitotic mrnas participates precedes prometaphase ribonucleic rnas transit u2os underscored
Tagcloud (Intersection) ?