ROCK2 and PPP1R12A

Number of citations of the paper that reports this interaction (PMID 10601309)
113

Data Source:
HPRD (in vitro)

		ROCK2	PPP1R12A
Gene Name		Rho-associated, coiled-coil containing protein kinase 2	protein phosphatase 1, regulatory subunit 12A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol Plasma Membrane Spindle Pole Centrosome Cytoplasmic Ribonucleoprotein Granule	Kinetochore Nucleoplasm Cytoplasm Centrosome Focal Adhesion Actin Cytoskeleton Contractile Fiber PTW/PP1 Phosphatase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Structural Molecule Activity Protein Binding ATP Binding Rho GTPase Binding Poly(A) RNA Binding Metal Ion Binding	Enzyme Inhibitor Activity Signal Transducer Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Cytokinesis Neural Tube Closure Protein Phosphorylation Smooth Muscle Contraction Rho Protein Signal Transduction Axon Guidance Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Centrosome Duplication Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Regulation Of Circadian Rhythm Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Rhythmic Process Dendrite Morphogenesis Centrosome Duplication Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Dephosphorylation Mitotic Nuclear Division Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleocytoplasmic Transport Centrosome Organization
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		3 interactors: MAGEC1 PPP1R12A STAU1	12 interactors: ATXN10 DMPK IL16 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG
Entrez ID		9475	4659
HPRD ID		04922	03606
Ensembl ID		ENSG00000134318	ENSG00000058272
Uniprot IDs		O75116	B2RAH5 O14974
PDB IDs		4L6Q	2KJY
Enriched GO Terms of Interacting Partners?		Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation By Virus Of Viral Protein Levels In Host Cell Intracellular MRNA Localization Positive Regulation Of Viral Genome Replication Regulation Of Phosphoprotein Phosphatase Activity	Neuron Projection Development Nervous System Development Regulation Of Organelle Organization Generation Of Neurons Regulation Of Cell Differentiation Neuron Development Rho Protein Signal Transduction Neurogenesis Regulation Of Stress Fiber Assembly Cell Development Neuron Differentiation Cell Projection Organization Regulation Of Locomotion Locomotion Ephrin Receptor Signaling Pathway Organelle Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cell Differentiation Cell Migration Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Blood Coagulation Cell Motility Hemostasis Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Keratinocyte Differentiation Regulation Of Cell-substrate Adhesion System Development Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Wound Healing Chemotaxis Ras Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Establishment Or Maintenance Of Cell Polarity Neuron Projection Morphogenesis Actin Filament-based Process Cellular Protein Modification Process Protein Phosphorylation Regulation Of Epidermal Cell Differentiation Regulation Of Cellular Component Movement Muscle System Process Response To Wounding Regulation Of Focal Adhesion Assembly
Tagcloud ?		arthritis autoimmunity balance box collagen diminished disrupted forkhead gammat instrumental kd025 man orphan p3 pharmacological proinflammatory promoters regulates regulatory restore rheumatoid rho rock1 secrete simultaneously stat5 subsets suppressive th17
Tagcloud (Difference) ?		arthritis autoimmunity balance box collagen diminished disrupted forkhead gammat instrumental kd025 man orphan p3 pharmacological proinflammatory promoters regulates regulatory restore rheumatoid rho rock1 secrete simultaneously stat5 subsets suppressive th17
Tagcloud (Intersection) ?