ROCK2 and PPP1R12A

Number of citations of the paper that reports this interaction (PubMedID 12563012)
46

Data Source:
HPRD (in vitro)

		ROCK2	PPP1R12A
Description		Rho associated coiled-coil containing protein kinase 2	protein phosphatase 1 regulatory subunit 12A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule	Kinetochore Stress Fiber Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Muscle Fiber PTW/PP1 Phosphatase Complex
	Molecular Function	Nucleotide Binding Protease Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Structural Molecule Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Endopeptidase Activator Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Mitotic Cytokinesis Epithelial To Mesenchymal Transition Response To Ischemia Aortic Valve Morphogenesis Protein Phosphorylation Smooth Muscle Contraction Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Centrosome Duplication Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Regulation Of Nervous System Process Positive Regulation Of Connective Tissue Growth Factor Production Regulation Of Actin Cytoskeleton Organization Regulation Of Circadian Rhythm Stress Fiber Assembly Positive Regulation Of MAPK Cascade Host-mediated Perturbation Of Viral Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Keratinocyte Differentiation Positive Regulation Of Phosphate Metabolic Process Rhythmic Process Embryonic Morphogenesis Centrosome Duplication Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Positive Regulation Of Fibroblast Growth Factor Production Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Regulation Of Cellular Response To Hypoxia Regulation Of Cell Junction Assembly Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Cellular Response To Acetylcholine Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Neuron Projection Morphogenesis Cellular Response To Xenobiotic Stimulus Regulation Of Establishment Of Endothelial Barrier
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOH GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS	Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Fasudil Y-27632 Fostamatinib Ripasudil Netarsudil Belumosudil
Diseases
GWAS		Appendicular lean mass ( 33097823) LDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494)	Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		7 interacting genes: CDKN3 MAGEC1 PPP1R12A PTPRF RNF10 STAU1 UBE2I	18 interacting genes: CDK1 CDKN3 CHEK1 CHEK2 DMPK IL16 ILK KDM1A MPRIP PLK1 PPP1CB PRKG1 RHOA ROCK1 ROCK2 SETD7 USP7 YWHAG
Entrez ID		9475	4659
HPRD ID		04922	03606
Ensembl ID		ENSG00000134318	ENSG00000058272
Uniprot IDs		A0A2P9DU05 O75116 Q14DU5	B2RAH5 O14974
PDB IDs		4L6Q 4WOT 5U7Q 5U7R 6ED6 6P5M 6P5P 7JNT 7JOV 7P6N 8GDS 8X8X 8X8Y 8X8Z 8X92 9EP8	2KJY 5HUZ
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Modification Process Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Protein Dephosphorylation Dephosphorylation Negative Regulation Of Receptor Binding Chondroitin Sulfate Proteoglycan Binding Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Glutamatergic Synapse LncRNA-mediated Post-transcriptional Gene Silencing Positive Regulation By Virus Of Viral Protein Levels In Host Cell RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding SUMO Conjugating Enzyme Activity Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane PTW/PP1 Phosphatase Complex Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Mitotic Nuclear Membrane Reassembly Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Anterograde Dendritic Transport	Protein Serine/threonine Kinase Activity Protein Modification Process Intracellular Signal Transduction Protein Phosphorylation Protein Kinase Activity Protein Serine Kinase Activity Phosphorylation Kinase Activity Regulation Of Circadian Rhythm Mitotic Nuclear Membrane Disassembly Microtubule Cytoskeleton Organization Involved In Mitosis G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Protein Metabolic Process Mitotic Cell Cycle Phase Transition Nuclear Membrane Disassembly Membrane Disassembly Cell Cycle Phase Transition Mitotic Cytokinesis Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Chromosome, Telomeric Region Intracellular Signaling Cassette Rho-dependent Protein Serine/threonine Kinase Activity Nuclear Envelope Organization Nucleotide Binding Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Focal Adhesion Regulation Of Metabolic Process Cytoskeleton Organization Phosphate-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Signal Transduction ATP Binding Regulation Of Muscle System Process Positive Regulation Of Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Metabolic Process Regulation Of DNA Metabolic Process Cytosol Regulation Of Cell Adhesion Regulation Of Macromolecule Metabolic Process Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Bicellular Tight Junction Assembly Regulation Of Organelle Organization Regulation Of Cellular Response To Stress Regulation Of Gene Expression Blood Vessel Diameter Maintenance
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