STAU1 and RPS6

Number of citations of the paper that reports this interaction (PubMedID 15121898)
58

Data Source:
HPRD (in vitro)

		STAU1	RPS6
Description		staufen double-stranded RNA binding protein 1	ribosomal protein S6
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Microtubule Associated Complex Plasma Membrane Cytoplasmic Stress Granule Membrane Dendrite Dendrite Cytoplasm Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Cell Body Extracellular Exosome Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Dendrite Small-subunit Processome Cytoplasmic Ribonucleoprotein Granule Cell Body Presynapse GABA-ergic Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding Protein Binding Protein Phosphatase 1 Binding	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding
	Biological Process	LncRNA-mediated Post-transcriptional Gene Silencing Germ Cell Development Intracellular MRNA Localization Cellular Response To Oxidative Stress Protein Localization To Synapse Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Modulation Of Chemical Synaptic Transmission Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Modification Of Postsynaptic Structure Positive Regulation Of Long-term Synaptic Potentiation	Ribosomal Small Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Cell Population Proliferation TOR Signaling Response To Insulin Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Cellular Response To Ethanol Negative Regulation Of Bicellular Tight Junction Assembly
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation mTORC1-mediated signalling SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Response of EIF2AK4 (GCN2) to amino acid deficiency Nuclear events stimulated by ALK signaling in cancer SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Artenimol
Diseases
GWAS		Anger ( 24489884) Appendicular lean mass ( 33097823) Change in quality of life in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease ( 31299468) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 32581322) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196 25282103) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889 31518406) Loneliness (MTAG) ( 29970889) Waist circumference adjusted for body mass index ( 28552196)	Total cholesterol levels ( 29083408)
Interacting Genes		49 interacting genes: ADARB1 APP CASC3 CDC42 CEBPA CFTR CSNK2B DHX9 DYNC1I1 FMR1 FOXP1 GLRX3 HNRNPU INA IQGAP1 KIF2B LINC00624 LONRF1 MAP1B MAPT MYH1 NCBP1 NCL NEIL3 NKRF NXT1 OGT PABPC1 PABPN1 PPP1CA RAC1 RASA1 ROCK2 RPL28 RPL6 RPL7A RPLP0 RPS6 SPP1 SRPK1 STRBP TAX1BP3 TINCR TUBB TUBB4A UBE2D3 UPF1 USP7 ZMAT3	20 interacting genes: ATF4 DUX4 EIF4ENIF1 ERCC6 FNDC3B FRS2 MTOR MYOM2 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH PTEN RPS6KB1 RPS6KB2 STAU1 UPF2 USP7
Entrez ID		6780	6194
HPRD ID		03422	01592
Ensembl ID		ENSG00000124214	ENSG00000137154
Uniprot IDs		B3KRE0 O95793 Q59F99 Q6PJX3	A2A3R6 P62753
PDB IDs		4DKK 6HTU 6SDW 6SDY	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6F4P 6F4Q 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7QVP 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 7ZJW 7ZJX 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Cytoplasmic Ribonucleoprotein Granule Ribonucleoprotein Complex RNA Binding Cytosol Cytoplasm Nucleus Regulation Of Translation Regulation Of MRNA Metabolic Process MRNA Export From Nucleus Dendrite MRNA Transport Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing RNA Export From Nucleus RNA Transport Postsynapse Negative Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Viral Process Cytoskeleton-dependent Intracellular Transport Cytoplasmic Translation Nuclear Export Negative Regulation Of Metabolic Process Nucleobase-containing Compound Transport Negative Regulation Of Macromolecule Metabolic Process Regulation Of Viral Process MRNA Processing Cell Body Regulation Of Cytoplasmic Translation CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleic Acid Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Protein-containing Complex Binding MRNA Binding Cytosolic Ribosome Positive Regulation Of Supramolecular Fiber Organization Transport Along Microtubule Regulation Of Supramolecular Fiber Organization Nuclear-transcribed MRNA Catabolic Process Cellular Localization Regulation Of RNA Splicing Regulation Of Viral Life Cycle Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation	TORC1 Signaling TOR Signaling Cellular Response To Nutrient Levels Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Regulation Of Protein Metabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Translational Initiation Cytoplasm Positive Regulation Of Transcription By RNA Polymerase I PML Body Negative Regulation Of TORC2 Signaling Response To Nutrient Levels Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of TOR Signaling Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Protein Serine Kinase Activity Negative Regulation Of Cell Size Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Protein Serine/threonine Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Transcription-coupled Nucleotide-excision Repair Cellular Response To Leucine Starvation Regulation Of Translation Regulation Of Cellular Response To Insulin Stimulus Regulation Of TORC2 Signaling Cytoplasmic Ribonucleoprotein Granule Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway TORC2 Signaling Vascular Endothelial Cell Response To Fluid Shear Stress Myelin Maintenance Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Tyrosine Kinase Activator Activity Signal Transduction Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase III Autophagosome Assembly Cellular Response To Laminar Fluid Shear Stress Cellular Response To Stress Autophagosome Organization Protein Kinase Activity Negative Regulation Of Autophagy Response To Laminar Fluid Shear Stress Positive Regulation Of Catabolic Process Cytoplasmic Translation
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