ROCK2

Description		Rho associated coiled-coil containing protein kinase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleotide Binding Protease Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Structural Molecule Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Endopeptidase Activator Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Cytokinesis Epithelial To Mesenchymal Transition Response To Ischemia Aortic Valve Morphogenesis Protein Phosphorylation Smooth Muscle Contraction Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Centrosome Duplication Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Regulation Of Nervous System Process Positive Regulation Of Connective Tissue Growth Factor Production Regulation Of Actin Cytoskeleton Organization Regulation Of Circadian Rhythm Stress Fiber Assembly Positive Regulation Of MAPK Cascade Host-mediated Perturbation Of Viral Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Keratinocyte Differentiation Positive Regulation Of Phosphate Metabolic Process Rhythmic Process Embryonic Morphogenesis Centrosome Duplication Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Positive Regulation Of Fibroblast Growth Factor Production Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Regulation Of Cellular Response To Hypoxia Regulation Of Cell Junction Assembly Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Cellular Response To Acetylcholine Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOH GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS
Drugs		Fasudil Y-27632 Fostamatinib Ripasudil Netarsudil Belumosudil
Diseases
GWAS		Appendicular lean mass ( 33097823) LDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		7 interacting genes: CDKN3 MAGEC1 PPP1R12A PTPRF RNF10 STAU1 UBE2I
Entrez ID		9475
HPRD ID		04922
Ensembl ID		ENSG00000134318
Uniprot IDs		A0A2P9DU05 O75116 Q14DU5
PDB IDs		4L6Q 4WOT 5U7Q 5U7R 6ED6 6P5M 6P5P 7JNT 7JOV 7P6N 8GDS 8X8X 8X8Y 8X8Z 8X92 9EP8
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Modification Process Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Protein Dephosphorylation Dephosphorylation Negative Regulation Of Receptor Binding Chondroitin Sulfate Proteoglycan Binding Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Glutamatergic Synapse LncRNA-mediated Post-transcriptional Gene Silencing Positive Regulation By Virus Of Viral Protein Levels In Host Cell RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding SUMO Conjugating Enzyme Activity Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane PTW/PP1 Phosphatase Complex Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Mitotic Nuclear Membrane Reassembly Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Anterograde Dendritic Transport
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