ROCK2

Gene Name		Rho-associated, coiled-coil containing protein kinase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol Plasma Membrane Spindle Pole Centrosome Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Serine/threonine Kinase Activity Structural Molecule Activity Protein Binding ATP Binding Rho GTPase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Cytokinesis Neural Tube Closure Protein Phosphorylation Smooth Muscle Contraction Rho Protein Signal Transduction Axon Guidance Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Centrosome Duplication Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Regulation Of Circadian Rhythm Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Rhythmic Process Dendrite Morphogenesis Centrosome Duplication Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: MAGEC1 PPP1R12A STAU1
Entrez ID		9475
HPRD ID		04922
Ensembl ID		ENSG00000134318
Uniprot IDs		O75116
PDB IDs		4L6Q
Enriched GO Terms of Interacting Partners?		Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation By Virus Of Viral Protein Levels In Host Cell Intracellular MRNA Localization Positive Regulation Of Viral Genome Replication Regulation Of Phosphoprotein Phosphatase Activity
Tagcloud ?		arthritis autoimmunity balance box collagen diminished disrupted forkhead gammat instrumental kd025 man orphan p3 pharmacological proinflammatory promoters regulates regulatory restore rheumatoid rho rock1 secrete simultaneously stat5 subsets suppressive th17