STAU1 and NEIL3

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		STAU1	NEIL3
Description		staufen double-stranded RNA binding protein 1	nei like DNA glycosylase 3
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Microtubule Associated Complex Plasma Membrane Cytoplasmic Stress Granule Membrane Dendrite Dendrite Cytoplasm Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Cell Body Extracellular Exosome Glutamatergic Synapse	Nucleus Nucleoplasm Chromosome
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding Protein Binding Protein Phosphatase 1 Binding	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding
	Biological Process	LncRNA-mediated Post-transcriptional Gene Silencing Germ Cell Development Intracellular MRNA Localization Cellular Response To Oxidative Stress Protein Localization To Synapse Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Modulation Of Chemical Synaptic Transmission Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Modification Of Postsynaptic Structure Positive Regulation Of Long-term Synaptic Potentiation	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs
Drugs
Diseases
GWAS		Anger ( 24489884) Appendicular lean mass ( 33097823) Change in quality of life in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease ( 31299468) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 32581322) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196 25282103) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889 31518406) Loneliness (MTAG) ( 29970889) Waist circumference adjusted for body mass index ( 28552196)	Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)
Interacting Genes		49 interacting genes: ADARB1 APP CASC3 CDC42 CEBPA CFTR CSNK2B DHX9 DYNC1I1 FMR1 FOXP1 GLRX3 HNRNPU INA IQGAP1 KIF2B LINC00624 LONRF1 MAP1B MAPT MYH1 NCBP1 NCL NEIL3 NKRF NXT1 OGT PABPC1 PABPN1 PPP1CA RAC1 RASA1 ROCK2 RPL28 RPL6 RPL7A RPLP0 RPS6 SPP1 SRPK1 STRBP TAX1BP3 TINCR TUBB TUBB4A UBE2D3 UPF1 USP7 ZMAT3	54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B
Entrez ID		6780	55247
HPRD ID		03422	16407
Ensembl ID		ENSG00000124214	ENSG00000109674
Uniprot IDs		B3KRE0 O95793 Q59F99 Q6PJX3	Q8TAT5
PDB IDs		4DKK 6HTU 6SDW 6SDY	7JL5 7TMY
Enriched GO Terms of Interacting Partners?		Cytoplasmic Ribonucleoprotein Granule Ribonucleoprotein Complex RNA Binding Cytosol Cytoplasm Nucleus Regulation Of Translation Regulation Of MRNA Metabolic Process MRNA Export From Nucleus Dendrite MRNA Transport Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing RNA Export From Nucleus RNA Transport Postsynapse Negative Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Viral Process Cytoskeleton-dependent Intracellular Transport Cytoplasmic Translation Nuclear Export Negative Regulation Of Metabolic Process Nucleobase-containing Compound Transport Negative Regulation Of Macromolecule Metabolic Process Regulation Of Viral Process MRNA Processing Cell Body Regulation Of Cytoplasmic Translation CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleic Acid Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Protein-containing Complex Binding MRNA Binding Cytosolic Ribosome Positive Regulation Of Supramolecular Fiber Organization Transport Along Microtubule Regulation Of Supramolecular Fiber Organization Nuclear-transcribed MRNA Catabolic Process Cellular Localization Regulation Of RNA Splicing Regulation Of Viral Life Cycle Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation	RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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