EXOC1 and COLEC12

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		EXOC1	COLEC12
Description		exocyst complex component 1	collectin subfamily member 12
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body	Collagen Trimer Plasma Membrane Membrane Endocytic Vesicle Membrane Extracellular Matrix
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding	Scavenger Receptor Activity Protein Binding Galactose Binding Low-density Lipoprotein Particle Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Macroautophagy Defense Response To Virus Membrane Fission Vesicle Tethering Involved In Exocytosis	Regulation Of Immune System Process Phagocytosis, Recognition Defense Response Immune Response Carbohydrate Mediated Signaling Defense Response To Bacterium Plasma Membrane Raft Organization Innate Immune Response
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Cerebrospinal P-tau181p levels ( 28247064) Cervical cancer ( 23817570) Daytime sleep phenotypes ( 27126917) Urinary albumin excretion ( 32277301) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Blood protein levels ( 30072576) Coenzyme Q10 levels ( 27149984) Metabolic syndrome ( 29212154) Obesity-related traits ( 23251661) Schizophrenia x sex interaction ( 34099189) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		29 interacting genes: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST ITSN1 KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 NUP54 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SNCA SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIO	3 interacting genes: APP EXOC1 FBXO7
Entrez ID		55763	81035
HPRD ID		07615	06358
Ensembl ID		ENSG00000090989	ENSG00000158270
Uniprot IDs		Q9NV70	Q5KU26
PDB IDs			2OX8
Enriched GO Terms of Interacting Partners?		Microtubule Binding Microtubule-based Process Cytoskeleton Organelle Organization Phosphatidylinositol 3-kinase Inhibitor Activity Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Cellular Localization Cell Leading Edge Cell Projection Cytoskeleton Organization Positive Regulation Of Cell Size Regulation Of Cytoskeleton Organization Microtubule Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Cell Projection Organization Actin Binding Cytoplasmic Vesicle Positive Regulation Of Cellular Component Organization Guanyl-nucleotide Exchange Factor Activity Intracellular Transport Regulation Of Organelle Organization Phagophore Assembly Site Membrane Establishment Of Localization In Cell Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Synapse Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Negative Regulation Of Protein-containing Complex Assembly Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Microtubule-based Process Negative Regulation Of Cellular Component Organization Phagophore Assembly Site Ribophagy Protein-membrane Adaptor Activity Extrinsic Component Of Phagophore Assembly Site Membrane Positive Regulation Of Neuroblast Proliferation Lamellipodium Assembly Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Lamellipodium Assembly Involved In Ameboidal Cell Migration Regulation Of Endocytosis Positive Regulation Of Axon Extension	Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome Lumen Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Response To Endoplasmic Reticulum Stress Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Regulation Of Immune System Process Regulation Of Cell Activation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Interleukin-4-mediated Signaling Pathway Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Hemopoiesis Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Lewy Body Core Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Positive Regulation Of Small Molecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of PERK-mediated Unfolded Protein Response
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