EXOC1 and COLEC12

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		EXOC1	COLEC12
Gene Name		exocyst complex component 1	collectin sub-family member 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane	Collagen Trimer Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Scavenger Receptor Activity Galactose Binding Signaling Pattern Recognition Receptor Activity Low-density Lipoprotein Particle Binding Metal Ion Binding
	Biological Process	Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Membrane Organization	Pattern Recognition Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis, Recognition Defense Response Carbohydrate Mediated Signaling Innate Immune Response Protein Homooligomerization
Pathways		Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing	Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Cervical cancer ( 23817570)	Bipolar disorder and major depressive disorder (combined) ( 20351715) Obesity-related traits ( 23251661)
Protein-Protein Interactions		28 interactors: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST GOLGA4 KANSL1 KDM1A KIAA0226 KIAA1551 KIF5A LUC7L2 MACF1 NUF2 RALA RB1CC1 SFR1 SH3BP5 SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIM9 TRIO	2 interactors: APP EXOC1
Entrez ID		55763	81035
HPRD ID		07615	06358
Ensembl ID		ENSG00000090989	ENSG00000158270
Uniprot IDs		Q9NV70	Q5KU26
PDB IDs			2OX8
Enriched GO Terms of Interacting Partners?		Golgi To Plasma Membrane Transport Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Organization Locomotion Nervous System Development Post-Golgi Vesicle-mediated Transport Microtubule-based Process Regulation Of Cell Projection Organization Generation Of Neurons Regulation Of Autophagy TOR Signaling Organelle Organization Golgi To Plasma Membrane Protein Transport Neurogenesis Regulation Of Cell Size Regulation Of Cellular Component Size Chemotaxis Intracellular Signal Transduction Cellular Component Assembly Regulation Of Neuron Projection Development Vesicle-mediated Transport Autophagy Cellular Localization Axon Guidance Regulation Of Neurogenesis Positive Regulation Of Axon Extension Autophagic Vacuole Assembly Establishment Of Localization In Cell Regulation Of Primitive Erythrocyte Differentiation Lamellipodium Assembly Involved In Ameboidal Cell Migration Lamellipodium Assembly Microtubule Cytoskeleton Organization Cell Projection Organization Cell Communication Lamellipodium Organization Positive Regulation Of Neural Precursor Cell Proliferation Macroautophagy Cell Projection Morphogenesis Regulation Of Cell Development Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of SNARE Complex Assembly Cell Part Morphogenesis Cerebral Cortex Radially Oriented Cell Migration Axonogenesis Regulation Of Axon Extension Regulation Of Neuron Differentiation Regulation Of Organelle Organization Cell Cycle Response To External Stimulus Golgi Vesicle Transport	Synaptic Growth At Neuromuscular Junction Exocytosis Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Secretion By Cell Axon Choice Point Recognition Secretion Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Establishment Of Localization In Cell Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing
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