GALNT15 and PDCD1LG2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GALNT15	PDCD1LG2
Description		polypeptide N-acetylgalactosaminyltransferase 15	programmed cell death 1 ligand 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Transport Vesicle	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Endomembrane System Membrane
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine	Adaptive Immune Response Immune System Process Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Cellular Response To Lipopolysaccharide
Pathways		O-linked glycosylation of mucins	Co-inhibition by PD-1 PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Numerical cognitive ability ( 31620175) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Blood protein levels ( 30072576) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		18 interacting genes: CD200R1 CD79A CISD2 EVI2B FCRL6 FFAR2 FNDC9 GOLM1 IL27RA MR1 MUC1 PDCD1LG2 PDZK1IP1 SLC30A2 SLC7A1 SPSB2 SYNPR TMEM179B	20 interacting genes: ATP6V0C ERMP1 GALNT15 GPR37L1 KTN1 LRP10 MFSD6 PDCD1 RUSF1 SLC35H1 SLC38A1 SLC38A7 SLC41A2 SLC7A1 SMIM3 TAS2R10 TMEM147 TMEM218 TMEM239 TMEM97
Entrez ID		117248	80380
HPRD ID		13563	16147
Ensembl ID		ENSG00000131386	ENSG00000197646
Uniprot IDs		C9JGI4 Q4G146 Q8N3T1	Q9BQ51
PDB IDs			6UMT 8J3V
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane External Side Of Plasma Membrane Negative Regulation Of T Cell Migration Positive Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Lymphocyte Migration Immune Response Positive Regulation Of Neutrophil Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Negative Regulation Of T Cell Extravasation Negative Regulation Of Mononuclear Cell Migration Regulation Of T Cell Migration Negative Regulation Of Interleukin-6 Production Transmembrane Signaling Receptor Activity Negative Regulation Of Leukocyte Migration	Membrane Glutamine Transport L-glutamine Transmembrane Transporter Activity Amino Acid Transmembrane Transport Amino Acid Transport
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