GALNT15 and SPSB2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GALNT15	SPSB2
Gene Name		polypeptide N-acetylgalactosaminyltransferase 15	splA/ryanodine receptor domain and SOCS box containing 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Transport Vesicle	Cellular_component Cytoplasm
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Protein O-linked Glycosylation O-glycan Processing Post-translational Protein Modification Cellular Protein Metabolic Process	Biological_process Protein Ubiquitination Intracellular Signal Transduction
Pathways		Post-translational protein modification O-linked glycosylation of mucins O-linked glycosylation	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MUC1 SPSB2	6 interactors: APP DDX4 GALNT15 NOS2 PAWR PRMT1
Entrez ID		117248	84727
HPRD ID		13563	13610
Ensembl ID		ENSG00000131386	ENSG00000111671
Uniprot IDs		B3KT16 C9JGI4 Q8N3T1	B7Z4W1 Q99619
PDB IDs			3EMW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Transcription By Competitive Promoter Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Histone H4 Acetylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Histone Acetylation Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein Acetylation Regulation Of Signal Transduction By P53 Class Mediator O-glycan Processing Regulation Of Histone Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Histone Modification Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Intracellular Signal Transduction DNA Damage Response, Signal Transduction By P53 Class Mediator Protein O-linked Glycosylation Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Intrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Checkpoint Post-translational Protein Modification Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle	Sexual Reproduction Reproduction Reproductive Process Spermatogenesis Male Gamete Generation Gamete Generation Cell Development Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Synaptic Growth At Neuromuscular Junction Negative Regulation Of Cell Differentiation Collateral Sprouting In Absence Of Injury Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Negative Regulation Of Megakaryocyte Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Peptidyl-cysteine S-nitrosylation Interleukin-2 Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Germ-line Stem Cell Maintenance Axon Choice Point Recognition Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Translation Interleukin-2 Production Arginine Catabolic Process Single Organism Reproductive Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Remodeling Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Guanylate Cyclase Activity Regulation Of Immune System Process Peptidyl-arginine N-methylation Regulation Of Cellular Respiration Developmental Process Protein Metabolic Process Histone H4-R3 Methylation Positive Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Immune System Process Nitric Oxide Biosynthetic Process Organelle Organization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Glycoprotein Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of B Cell Proliferation Innate Immune Response In Mucosa Histone Arginine Methylation
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