HOMER3 and LRRC7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOMER3	LRRC7
Description		homer scaffold protein 3	leucine rich repeat containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite Basal Part Of Cell Synapse Glutamatergic Synapse	Extracellular Region Cytoplasm Cytosol Adherens Junction Postsynaptic Density Basolateral Plasma Membrane Specific Granule Lumen Axon Initial Segment Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding	Protein Binding Protein Kinase Binding
	Biological Process	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry	Positive Regulation Of Neuron Projection Development Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 21784300) Body mass index ( 24348519) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hypertension risk in short sleep duration ( 22322875) Obesity-related traits ( 23251661) Orofacial clefts ( 22419666) Psoriasis ( 25939698) Type 2 diabetes ( 31049640)
Interacting Genes		90 interacting genes: ABI1 ABI2 ABI3 APP ARL13B C1orf116 C4orf17 CCDC120 CCDC141 CCDC187 CDC37 CDK18 CEBPA CEBPB CFTR CWF19L2 DRC4 DVL3 DYNLL1 DYNLL2 EAF1 EFHC1 EIF3D FAM161B FAM90A1 FAT1 FMR1 FXR1 FXR2 GGN GRM5 HOMER1 HOXB5 INCA1 ITPR1 KANK2 KANK4 KDM1A KRTAP19-7 LHX2 LNX1 LRRC7 LSM14B MDM1 MEOX1 MFAP1 MIA3 MOS MSS51 NEBL NTAQ1 OTX2 PAX6 PAX7 PKN1 PLAAT5 POLI POM121 PPP1R18 PRCC PRR35 PSMA1 PSMA2 PSMC5 PSORS1C2 RBM14 RBM22 RUNX1T1 RYR1 SAXO1 SAXO4 SCNM1 SDCBP SHANK3 SLAIN1 SMR3B SNCA SNRPF SRPK2 TBC1D22B TOX2 TRPC1 TSC1 USP2 WIPF1 ZBTB4 ZNF19 ZNF35 ZNF414 ZNF655	18 interacting genes: ACTN2 ACTN4 ADGRB1 CAMK2A CAMK2G CDH2 CNKSR2 CTNND2 EPS15L1 ERBB2 ERBB3 ERBB4 HOMER3 HOMEZ NQO2 PPP1R9B TOR1A VANGL2
Entrez ID		9454	57554
HPRD ID		07270	09930
Ensembl ID		ENSG00000051128	ENSG00000033122
Uniprot IDs		Q9NSC5	A0A075B6E9 A0A494C1A4 B1AKT2
PDB IDs		2P8V 3CVF
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dendritic Spine Cytoplasm Postsynapse Actin-based Cell Projection Postsynaptic Density SCAR Complex C/EBP Complex HMG Box Domain Binding Signaling Adaptor Activity Neuron Projection Growth Cone Filopodium CHOP-C/EBP Complex Cytoplasmic Ribonucleoprotein Granule Filopodium Tip Growth Cone Regulation Of Synaptic Plasticity Translation Regulator Activity Protein Tetramerization Glutamate Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Neurogenesis Cytoskeleton Cytoskeletal Anchor Activity Regulation Of Cytosolic Calcium Ion Concentration RNA Strand Annealing Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Synapse Organization Telencephalon Regionalization Dorsal/ventral Pattern Formation Regulation Of Nervous System Process Regulation Of Cytoskeleton Organization Regulation Of Nervous System Development Intracellular Membraneless Organelle Scaffold Protein Binding Negative Regulation Of Centriole Replication Positive Regulation Of Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic 14-3-3 Protein Binding RNA Splicing Regulation Of Neurogenesis MRNA Splicing, Via Spliceosome Proteasome Core Complex, Alpha-subunit Complex Neuron Spine Regulation Of Cell Projection Organization Developmental Maturation	Postsynaptic Density Cortical Actin Cytoskeleton Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Protein Localization To Cell Periphery Regulation Of Protein Localization Peripheral Nervous System Development ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Basolateral Plasma Membrane Regulation Of Protein Localization To Cell Surface Regulation Of Cellular Localization Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Dendritic Spine Glutamatergic Synapse Cellular Response To Epidermal Growth Factor Stimulus Cell Projection Response To Epidermal Growth Factor Regulation Of Metal Ion Transport Intracellular Protein Localization Synapse Regulation Of Protein Localization To Membrane ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Anchoring Junction Postsynaptic Actin Cytoskeleton Cell Junction Regulation Of Monoatomic Ion Transport Plasma Membrane Wound Healing Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Projection Organization Cell Junction Organization Dendrite Regulation Of Transport Neuron Projection Development Synapse Organization Pseudopodium Postsynaptic Density Membrane Schwann Cell Development
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