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LRRC7 and ACTN2
Number of citations of the paper that reports this interaction (PMID
16120608
)
37
Data Source:
HPRD
(in vitro)
LRRC7
ACTN2
Gene Name
leucine rich repeat containing 7
actinin, alpha 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Postsynaptic Density
Cell Junction
Postsynaptic Membrane
Extracellular Region
Cytosol
Cytoskeleton
Actin Filament
Focal Adhesion
Z Disc
Filopodium
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Dendritic Spine
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
LIM Domain Binding
Thyroid Hormone Receptor Coactivator Activity
Titin Binding
Identical Protein Binding
Ion Channel Binding
Protein Dimerization Activity
Actin Filament Binding
FATZ Binding
Titin Z Domain Binding
Biological Process
Platelet Degranulation
Cell Adhesion
Synaptic Transmission
Blood Coagulation
Microspike Assembly
Muscle Filament Sliding
Platelet Activation
Regulation Of Membrane Potential
Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Potassium Ion Transport
Focal Adhesion Assembly
Protein Homotetramerization
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Receptor Activity
Pathways
Striated Muscle Contraction
Platelet degranulation
CREB phosphorylation through the activation of Ras
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Response to elevated platelet cytosolic Ca2+
CREB phosphorylation through the activation of CaMKII
Nephrin interactions
Platelet activation, signaling and aggregation
Unblocking of NMDA receptor, glutamate binding and activation
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Ras activation uopn Ca2+ infux through NMDA receptor
Transmission across Chemical Synapses
Post NMDA receptor activation events
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder (
21784300
)
Hypertension risk in short sleep duration (
22322875
)
Obesity-related traits (
23251661
)
Orofacial clefts (
22419666
)
Protein-Protein Interactions
11 interactors:
ACTN2
ACTN4
BAI1
CAMK2A
CAMK2G
CDH2
CNKSR2
CTNND2
HOMEZ
NQO2
TOR1A
59 interactors:
ACTN3
ADAM12
ADORA2A
ANG
ATXN2
ATXN7
BRMS1L
CAMK2A
CAMK2D
CAMK2G
CAPN1
COIL
DISC1
DLG1
DLG4
EPS8L1
ERBB2IP
FAM154A
FBXL22
GRIN1
GRIN2B
ITGB3BP
KAT2B
KCNA4
KCNA5
KCNN2
LDB3
LRP12
LRRC7
MED14
MICALL2
MOS
MYOZ1
MYOZ2
MYOZ3
MYPN
NCOA2
NCOR1
NOS3
NR1I2
NRIP1
PALLD
PDLIM1
PDLIM3
PKD2
RAVER1
RPL35
RTP5
SELE
SNAI1
SNW1
SP100
SSX2IP
ST7
SYNPO2
TNN
TTN
UTRN
ZNF446
Entrez ID
57554
88
HPRD ID
09930
00019
Ensembl ID
ENSG00000033122
ENSG00000077522
Uniprot IDs
Q96NW7
B2RCS5
P35609
Q59FD9
PDB IDs
1H8B
1HCI
1QUU
Enriched GO Terms of Interacting Partners
?
Regulation Of Ion Transport
Regulation Of Protein Localization To Cell Surface
Regulation Of Cellular Response To Heat
Positive Regulation Of Ion Transport
Cell Junction Assembly
Cell-cell Junction Organization
Synaptic Transmission
Cell Adhesion
Positive Regulation Of Transport
Positive Regulation Of Ion Transmembrane Transporter Activity
Positive Regulation Of Transporter Activity
Regulation Of Synaptic Transmission
Cellular Response To Heat
Platelet Degranulation
Cell-cell Signaling
Positive Regulation Of Ion Transmembrane Transport
Adherens Junction Organization
Protein Oligomerization
Cellular Component Assembly
Positive Regulation Of Endocytosis
Regulation Of Signaling
Response To Heat
Establishment Of Localization In Cell
Protein Localization To Tight Junction
Positive Regulation Of Synaptic Vesicle Endocytosis
Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of Pinocytosis
ER-associated Misfolded Protein Catabolic Process
Secretion By Cell
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Sodium:proton Antiporter Activity
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Cellular Response To Interferon-gamma
Nuclear Membrane Organization
Wound Healing
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Synaptic Plasticity
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Sodium:proton Antiporter Activity
Microspike Assembly
Peroxisome Proliferator Activated Receptor Signaling Pathway
Secretion
Response To Interferon-gamma
Cellular Localization
Regulation Of Relaxation Of Cardiac Muscle
Regulation Of Endocytosis
Response To Temperature Stimulus
Regulation Of Calcium Ion Transport
Response To Wounding
Cytoskeleton Organization
Regulation Of Ion Transport
Organelle Organization
Cell Communication
Actin Filament-based Process
Signaling
Cellular Component Assembly
Positive Regulation Of Cellular Metabolic Process
Regulation Of Ion Transmembrane Transport
Anatomical Structure Development
Synaptic Transmission
Positive Regulation Of Metabolic Process
Cell Development
Signal Transduction
Movement Of Cell Or Subcellular Component
Cell Differentiation
Cell-cell Signaling
Regulation Of Cellular Process
Rhythmic Process
Developmental Process
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Receptor Signaling Pathway
Actin Cytoskeleton Organization
Anatomical Structure Morphogenesis
Protein Complex Assembly
Regulation Of Potassium Ion Transport
Striated Muscle Cell Differentiation
Regulation Of Signaling
Anatomical Structure Formation Involved In Morphogenesis
Response To Organic Substance
Regulation Of Sodium Ion Transport
Response To Abiotic Stimulus
Muscle System Process
Negative Regulation Of Transport
Striated Muscle Cell Development
Positive Regulation Of Cellular Biosynthetic Process
Myofibril Assembly
Establishment Or Maintenance Of Apical/basal Cell Polarity
Transcription Initiation From RNA Polymerase II Promoter
Cell Adhesion
Muscle Cell Development
Cellular Calcium Ion Homeostasis
Regulation Of Receptor Internalization
Regulation Of Cellular Response To Heat
Response To Stimulus
Regulation Of Histone Deacetylase Activity
Calcium Ion Homeostasis
Regulation Of Calcium Ion Transport
Locomotion
Negative Regulation Of Ion Transport
Tagcloud
?
actinin
barr
cd99
cdk8
dnajb2
e2f
e2f2
ebv
epstein
fatigue
hsp40
hybridized
indicative
infectious
infective
irritability
isg20
malaise
microarrays
mononucleosis
oligonucleotides
pbmc
persist
pilot
recovered
resolve
somnolence
spotted
uneventfully
Tagcloud (Difference)
?
actinin
barr
cd99
cdk8
dnajb2
e2f
e2f2
ebv
epstein
fatigue
hsp40
hybridized
indicative
infectious
infective
irritability
isg20
malaise
microarrays
mononucleosis
oligonucleotides
pbmc
persist
pilot
recovered
resolve
somnolence
spotted
uneventfully
Tagcloud (Intersection)
?