HOMER3 and C4orf17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOMER3	C4orf17
Description		homer scaffold protein 3	chromosome 4 open reading frame 17
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite Basal Part Of Cell Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding	Protein Binding
	Biological Process	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Alcohol consumption (drinks per week) ( 30643258) Celiac disease ( 23936387) Eating disorders ( 23568457) Metabolite levels (MHPG) ( 23319000) Pre-treatment viral load in HIV-1 infection ( 31219150) Regular attendance at a pub or social club ( 29970889) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		90 interacting genes: ABI1 ABI2 ABI3 APP ARL13B C1orf116 C4orf17 CCDC120 CCDC141 CCDC187 CDC37 CDK18 CEBPA CEBPB CFTR CWF19L2 DRC4 DVL3 DYNLL1 DYNLL2 EAF1 EFHC1 EIF3D FAM161B FAM90A1 FAT1 FMR1 FXR1 FXR2 GGN GRM5 HOMER1 HOXB5 INCA1 ITPR1 KANK2 KANK4 KDM1A KRTAP19-7 LHX2 LNX1 LRRC7 LSM14B MDM1 MEOX1 MFAP1 MIA3 MOS MSS51 NEBL NTAQ1 OTX2 PAX6 PAX7 PKN1 PLAAT5 POLI POM121 PPP1R18 PRCC PRR35 PSMA1 PSMA2 PSMC5 PSORS1C2 RBM14 RBM22 RUNX1T1 RYR1 SAXO1 SAXO4 SCNM1 SDCBP SHANK3 SLAIN1 SMR3B SNCA SNRPF SRPK2 TBC1D22B TOX2 TRPC1 TSC1 USP2 WIPF1 ZBTB4 ZNF19 ZNF35 ZNF414 ZNF655	14 interacting genes: ABI2 CHD3 COPS6 CRK GRN HOMER3 KDM1A LONRF1 NCK2 PRMT1 SH3GL3 SUV39H1 TUBA4A ZNF417
Entrez ID		9454	84103
HPRD ID		07270	12825
Ensembl ID		ENSG00000051128	ENSG00000138813
Uniprot IDs		Q9NSC5	Q53FE4
PDB IDs		2P8V 3CVF
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dendritic Spine Cytoplasm Postsynapse Actin-based Cell Projection Postsynaptic Density SCAR Complex C/EBP Complex HMG Box Domain Binding Signaling Adaptor Activity Neuron Projection Growth Cone Filopodium CHOP-C/EBP Complex Cytoplasmic Ribonucleoprotein Granule Filopodium Tip Growth Cone Regulation Of Synaptic Plasticity Translation Regulator Activity Protein Tetramerization Glutamate Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Neurogenesis Cytoskeleton Cytoskeletal Anchor Activity Regulation Of Cytosolic Calcium Ion Concentration RNA Strand Annealing Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Synapse Organization Telencephalon Regionalization Dorsal/ventral Pattern Formation Regulation Of Nervous System Process Regulation Of Cytoskeleton Organization Regulation Of Nervous System Development Intracellular Membraneless Organelle Scaffold Protein Binding Negative Regulation Of Centriole Replication Positive Regulation Of Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic 14-3-3 Protein Binding RNA Splicing Regulation Of Neurogenesis MRNA Splicing, Via Spliceosome Proteasome Core Complex, Alpha-subunit Complex Neuron Spine Regulation Of Cell Projection Organization Developmental Maturation	Signaling Adaptor Activity Regulation Of Cellular Response To Stress Regulation Of Developmental Process Enzyme Binding Blastocyst Hatching Cytoskeletal Anchor Activity Signaling Receptor Complex Adaptor Activity Regulation Of Neuron Projection Development Histone Methyltransferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Positive Regulation Of Aspartic-type Peptidase Activity GATOR1 Complex Binding Regulation Of DNA Repair Chromatin Remodeling Negative Regulation Of Biosynthetic Process Helper T Cell Diapedesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphorylated Amino Acid Binding Receptor Tyrosine Kinase Binding Scaffold Protein Binding Response To Cholecystokinin Positive Regulation Of Trophectodermal Cell Proliferation Zonula Adherens Assembly Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Cell Projection Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Kinase Binding SH3 Domain Binding Regulation Of Actin Cytoskeleton Organization Cerebral Cortex Development Regulation Of Actin Filament-based Process Cerebellar Neuron Development Negative Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Microglial Cell Activation Involved In Immune Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Lysosome Organization Astrocyte Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Wounding Trophectodermal Cell Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?