LRRC7 and TOR1A

Number of citations of the paper that reports this interaction (PubMedID 15767459)
22

Data Source:
HPRD (in vivo)

		LRRC7	TOR1A
Description		leucine rich repeat containing 7	torsin family 1 member A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Adherens Junction Postsynaptic Density Basolateral Plasma Membrane Specific Granule Lumen Axon Initial Segment Synapse Postsynaptic Membrane	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Synaptic Vesicle Endomembrane System Membrane Transport Vesicle Secretory Granule Growth Cone Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Cell Projection Synapse Extracellular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding	Nucleotide Binding Protein Binding ATP Binding Cytoskeletal Protein Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Identical Protein Binding Unfolded Protein Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Positive Regulation Of Neuron Projection Development Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane	Protein Deneddylation Protein Folding Response To Oxidative Stress Nuclear Envelope Organization Cell Adhesion Neuron Projection Development Protein Localization To Nucleus ERAD Pathway Wound Healing, Spreading Of Cells Intermediate Filament Cytoskeleton Organization Synaptic Vesicle Transport Synaptic Vesicle Membrane Organization Regulation Of Dopamine Uptake Involved In Synaptic Transmission Nuclear Membrane Organization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Protein Localization To Cell Surface
Pathways			Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 21784300) Body mass index ( 24348519) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hypertension risk in short sleep duration ( 22322875) Obesity-related traits ( 23251661) Orofacial clefts ( 22419666) Psoriasis ( 25939698) Type 2 diabetes ( 31049640)	Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Prostate cancer (early onset) ( 29892016)
Interacting Genes		18 interacting genes: ACTN2 ACTN4 ADGRB1 CAMK2A CAMK2G CDH2 CNKSR2 CTNND2 EPS15L1 ERBB2 ERBB3 ERBB4 HOMER3 HOMEZ NQO2 PPP1R9B TOR1A VANGL2	7 interacting genes: KRTAP10-7 LMNA LRRC7 MDFI SNCA TOR1AIP2 TOR1B
Entrez ID		57554	1861
HPRD ID		09930	06897
Ensembl ID		ENSG00000033122	ENSG00000136827
Uniprot IDs		A0A075B6E9 A0A494C1A4 B1AKT2	B3KPA1 O14656
PDB IDs			5J1S 5J1T 6OIF
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Cortical Actin Cytoskeleton Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Protein Localization To Cell Periphery Regulation Of Protein Localization Peripheral Nervous System Development ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Basolateral Plasma Membrane Regulation Of Protein Localization To Cell Surface Regulation Of Cellular Localization Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Dendritic Spine Glutamatergic Synapse Cellular Response To Epidermal Growth Factor Stimulus Cell Projection Response To Epidermal Growth Factor Regulation Of Metal Ion Transport Intracellular Protein Localization Synapse Regulation Of Protein Localization To Membrane ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Anchoring Junction Postsynaptic Actin Cytoskeleton Cell Junction Regulation Of Monoatomic Ion Transport Plasma Membrane Wound Healing Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Projection Organization Cell Junction Organization Dendrite Regulation Of Transport Neuron Projection Development Synapse Organization Pseudopodium Postsynaptic Density Membrane Schwann Cell Development	Protein Localization To Nucleus Protein Localization To Nuclear Envelope Membrane Organization Protein Localization To Organelle Negative Regulation Of Muscle Hypertrophy Cardiac Cell Development Nuclear Membrane Identical Protein Binding Negative Regulation Of Cardiac Muscle Hypertrophy Protein Sequestering Activity Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Negative Regulation Of Exocytosis Coronary Sinus Valve Morphogenesis Enzyme Inhibitor Activity Foregut Morphogenesis Negative Regulation Of Sperm Capacitation Alkylglycerophosphoethanolamine Phosphodiesterase Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Kinesin Binding Endoplasmic Reticulum Organization Protein-containing Complex Localization DNA Double-strand Break Attachment To Nuclear Envelope Regulation Of Cardiac Muscle Hypertrophy Structural Constituent Of Nuclear Lamina Axis Specification Notch Signaling Involved In Heart Development Endocardium Morphogenesis Mitral Valve Formation Positive Regulation Of Aorta Morphogenesis Coronary Vein Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Right Atrium Morphogenesis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Muscle Cell Development Intracellular Protein Localization Regulation Of Locomotion Import Into Nucleus Protein Import Into Nucleus MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
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