HOMER3 and PRCC

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		HOMER3	PRCC
Description		homer scaffold protein 3	proline rich mitotic checkpoint control factor
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite Basal Part Of Cell Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Protein Binding Protein Domain Specific Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding	Protein Binding
	Biological Process	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry	Regulation Of Cell Cycle
Pathways		Neurexins and neuroligins Neurexins and neuroligins	mRNA Splicing - Major Pathway
Drugs
Diseases			Renal cell carcinoma
GWAS			Sjögren's syndrome ( 28076899)
Interacting Genes		90 interacting genes: ABI1 ABI2 ABI3 APP ARL13B C1orf116 C4orf17 CCDC120 CCDC141 CCDC187 CDC37 CDK18 CEBPA CEBPB CFTR CWF19L2 DRC4 DVL3 DYNLL1 DYNLL2 EAF1 EFHC1 EIF3D FAM161B FAM90A1 FAT1 FMR1 FXR1 FXR2 GGN GRM5 HOMER1 HOXB5 INCA1 ITPR1 KANK2 KANK4 KDM1A KRTAP19-7 LHX2 LNX1 LRRC7 LSM14B MDM1 MEOX1 MFAP1 MIA3 MOS MSS51 NEBL NTAQ1 OTX2 PAX6 PAX7 PKN1 PLAAT5 POLI POM121 PPP1R18 PRCC PRR35 PSMA1 PSMA2 PSMC5 PSORS1C2 RBM14 RBM22 RUNX1T1 RYR1 SAXO1 SAXO4 SCNM1 SDCBP SHANK3 SLAIN1 SMR3B SNCA SNRPF SRPK2 TBC1D22B TOX2 TRPC1 TSC1 USP2 WIPF1 ZBTB4 ZNF19 ZNF35 ZNF414 ZNF655	8 interacting genes: CSNK2A1 EGFR HOMER3 MAD2L2 PPIL2 RBM10 SRSF2 TOE1
Entrez ID		9454	5546
HPRD ID		07270	01562
Ensembl ID		ENSG00000051128	ENSG00000143294
Uniprot IDs		Q9NSC5	A0A0S2Z456 Q92733 Q96FT4
PDB IDs		2P8V 3CVF
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dendritic Spine Cytoplasm Postsynapse Actin-based Cell Projection Postsynaptic Density SCAR Complex C/EBP Complex HMG Box Domain Binding Signaling Adaptor Activity Neuron Projection Growth Cone Filopodium CHOP-C/EBP Complex Cytoplasmic Ribonucleoprotein Granule Filopodium Tip Growth Cone Regulation Of Synaptic Plasticity Translation Regulator Activity Protein Tetramerization Glutamate Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Neurogenesis Cytoskeleton Cytoskeletal Anchor Activity Regulation Of Cytosolic Calcium Ion Concentration RNA Strand Annealing Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Synapse Organization Telencephalon Regionalization Dorsal/ventral Pattern Formation Regulation Of Nervous System Process Regulation Of Cytoskeleton Organization Regulation Of Nervous System Development Intracellular Membraneless Organelle Scaffold Protein Binding Negative Regulation Of Centriole Replication Positive Regulation Of Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic 14-3-3 Protein Binding RNA Splicing Regulation Of Neurogenesis MRNA Splicing, Via Spliceosome Proteasome Core Complex, Alpha-subunit Complex Neuron Spine Regulation Of Cell Projection Organization Developmental Maturation	Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process MRNA Metabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of DNA Repair RNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Recombination Negative Regulation Of Macromolecule Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Metabolic Process Multivesicular Body, Internal Vesicle Lumen RNA Processing RNA Splicing Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Protein Catabolic Process Regulation Of Chromosome Separation Regulation Of Cell Growth Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Speck MRNA Processing Regulation Of Cell Cycle Phase Transition Shc-EGFR Complex PML Body Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Regulation Of MRNA Splicing, Via Spliceosome Smooth Muscle Cell Apoptotic Process G Protein-coupled Glutamate Receptor Binding Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Chromosome Segregation Negative Regulation Of Biosynthetic Process Positive Regulation Of DNA Repair Epidermal Growth Factor Binding Regulation Of MRNA Processing Nucleic Acid Binding Negative Regulation Of Ribosome Biogenesis
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