IQCB1 and NECTIN3

Data Source: HiPPIP (Novel)

		IQCB1	NECTIN3
Name		IQ motif containing B1	nectin cell adhesion molecule 3
Structure		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Photoreceptor Connecting Cilium Extracellular Exosome	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Axon Dendrite Apical Junction Complex Cell-cell Contact Zone Synapse Postsynaptic Membrane Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane
	Molecular Function	Protein Binding Calmodulin Binding Enzyme Binding Protein-macromolecule Adaptor Activity BBSome Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Cell Projection Organization Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Cilium Assembly Cytosolic Ciliogenesis	Lens Morphogenesis In Camera-type Eye Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fertilization Symbiont Entry Into Host Cell Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Plasma Membrane Cochlea Morphogenesis Cell-cell Adhesion Regulation Of Postsynapse Assembly Protein Localization To Cell Junction
Pathways		Anchoring of the basal body to the plasma membrane	Adherens junctions interactions Nectin/Necl trans heterodimerization
Diseases		Senior-Loken syndrome	None
GWAS		Hemoglobin levels ( 32327693 ) Multiple sclerosis ( 24076602 31604244 ) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376 )	Feeling hurt ( 29500382 )
Novel Interactors		6 novel interactors: CD80 LMOD1 NECTIN3 TBL1X TRH UPK1B	1 novel interactors: IQCB1
Interacting Genes		12 interacting genes: CALM2 CALML3 KIF9 LDOC1 MARCHF7 MNS1 PCMT1 PDE9A SESTD1 SMARCD1 SPG21 TRIM32	24 interacting genes: AFDN CYSRT1 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-1 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-9 KRTAP9-3 NBPF19 NECTIN1 NECTIN2 NOTCH2NLA OTX1 PARD3 PICK1 PVR RGS20 TIGIT
Entrez ID		9657	25945
HPRD ID		11049	08454
Ensembl ID		ENSG00000173226	ENSG00000177707
Uniprot IDs		Q15051	Q9NQS3
PDB IDs		Not available	4FOM
GO Terms Enriched among Interactors		Detection Of Calcium Ion Regulation Of Cilium Assembly Regulation Of Organelle Assembly Calcium Channel Complex Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Calcineurin-mediated Signaling Myelin Sheath Negative Regulation Of Cell Population Proliferation Regulation Of Organelle Organization Thyrotropin-releasing Hormone Activity Positive Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of Cilium Assembly Actin Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production	Intermediate Filament Keratin Filament Susceptibility To T Cell Mediated Cytotoxicity Cell-cell Contact Zone Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell Adhesion Molecule Binding Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Identical Protein Binding Cell Adhesion Mediator Activity Adherens Junction Leukocyte Mediated Cytotoxicity Hair Cycle Virus Receptor Activity Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Lymphocyte Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cytosol Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of T Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Tight Junction Diencephalon Morphogenesis Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Bicellular Tight Junction Assembly Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Organization Cell Killing Tight Junction Assembly Tight Junction Organization Regulation Of Lymphocyte Mediated Immunity Sperm Mitochondrion Organization BBSome Binding Cell-cell Junction Coreceptor Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules