GAREM1 and CRKL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GAREM1	CRKL
Description		GRB2 associated regulator of MAPK1 subtype 1	CRK like proto-oncogene, adaptor protein
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GO Annotations	Cellular Component	Plasma Membrane	Nucleoplasm Cytoplasm Cytosol Neuromuscular Junction Protein-containing Complex Synapse Extrinsic Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding Proline-rich Region Binding	Phosphotyrosine Residue Binding RNA Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Identical Protein Binding Cadherin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Multicellular Organism Growth Positive Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus	Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Regulation Of Leukocyte Migration Outflow Tract Morphogenesis Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Animal Organ Morphogenesis Anterior/posterior Pattern Specification Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Fibroblast Growth Factor Endothelin Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Specialization Assembly Cerebellar Neuron Development Cellular Response To Interleukin-7 Chordate Pharynx Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration
Pathways			Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Left ventricular internal dimension in diastole ( 29403010) Left ventricular internal dimension in systole ( 29403010)	Mean platelet volume ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		5 interacting genes: CFTR CRK CRKL GRAP2 NCK2	78 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1
Entrez ID		64762	1399
HPRD ID		12685	03596
Ensembl ID		ENSG00000141441	ENSG00000099942
Uniprot IDs		Q9H706	P46109
PDB IDs		2DKZ	2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Helper T Cell Diapedesis Cerebellar Neuron Development Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Postsynaptic Specialization Organization Signaling Receptor Complex Adaptor Activity Regulation Of Rac Protein Signal Transduction T Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Dendrite Development Central Nervous System Neuron Development Regulation Of T Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Ephrin Receptor Signaling Pathway Lymphocyte Migration Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Protein Localization Regulation Of Lymphocyte Migration Hippocampus Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Scaffold Protein Binding Response To Transforming Growth Factor Beta Positive Regulation Of Small GTPase Mediated Signal Transduction Neuromuscular Junction Ras Protein Signal Transduction Positive Regulation Of Cell Adhesion Cerebral Cortex Development Regulation Of Cellular Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Protein Localization To Membrane Establishment Of Cell Polarity Regulation Of Dendrite Development Regulation Of Cell Communication Regulation Of Signaling Mononuclear Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Anion Channel Activity Positive Regulation Of Signaling	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction SH3 Domain Binding Phosphotyrosine Residue Binding Intracellular Signal Transduction Protein Tyrosine Kinase Activity Immune System Process Insulin Receptor Signaling Pathway Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Leukocyte Activation Immune Effector Process ERBB Signaling Pathway B Cell Receptor Signaling Pathway Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Cytosol Regulation Of Immune System Process B Cell Differentiation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Growth Factor Stimulus Plasma Membrane Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Binding Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway T Cell Activation Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Regulation Of Multicellular Organismal Development Ephrin Receptor Binding Regulation Of Leukocyte Proliferation
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