TOP3A and RECQL5

Number of citations of the paper that reports this interaction (PMID 10710432)
35

Data Source:
HPRD (in vitro, in vivo)

		TOP3A	RECQL5
Gene Name		topoisomerase (DNA) III alpha	RecQ protein-like 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Chromosome PML Body	Nucleus Nucleoplasm Nucleolus Cytoplasm DNA-directed RNA Polymerase II, Holoenzyme Nuclear Membrane
	Molecular Function	DNA Binding DNA Topoisomerase Type I Activity Protein Binding Zinc Ion Binding	RNA Polymerase II Core Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding ATP-dependent Helicase Activity
	Biological Process	DNA Topological Change Meiotic Nuclear Division	DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Mitotic Nuclear Division DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cell Division Chromosome Separation
Pathways		Meiotic recombination
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: BLM RECQL5	19 interactors: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11A MTSS1 NBN PLK1 POLR2A RAD50 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		7156	9400
HPRD ID		03145	04806
Ensembl ID		ENSG00000177302	ENSG00000108469
Uniprot IDs		B4DK80 B4DSJ0 Q13472	B3KQK2 O94762 Q6P4G0 Q8WYH5
PDB IDs			4BK0
Enriched GO Terms of Interacting Partners?		DNA Duplex Unwinding DNA Geometric Change DNA Recombination DNA Replication DNA Conformation Change Cellular Response To Camptothecin Cellular Response To Hydroxyurea Response To Camptothecin Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Negative Regulation Of Thymocyte Apoptotic Process Replication Fork Protection DNA Repair DNA Double-strand Break Processing Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Strand Renaturation Positive Regulation Of Alpha-beta T Cell Proliferation Cellular Response To DNA Damage Stimulus Replication Fork Processing Mitotic G2 DNA Damage Checkpoint Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Thymocyte Apoptotic Process Negative Regulation Of DNA-templated Transcription, Elongation Chromosome Separation Chromosome Organization Negative Regulation Of DNA Recombination Cell Cycle Process DNA Metabolic Process Negative Regulation Of T Cell Apoptotic Process Response To X-ray G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Alkaloid Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of T Cell Apoptotic Process Negative Regulation Of DNA Replication Cellular Response To Stress Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Leukocyte Apoptotic Process Cellular Response To Ionizing Radiation Alpha-beta T Cell Differentiation Regulation Of Lymphocyte Apoptotic Process Regulation Of DNA Recombination Alpha-beta T Cell Activation Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Division	DNA Conformation Change Positive Regulation Of Protein Autophosphorylation Meiotic Cell Cycle Regulation Of Protein Autophosphorylation G2 DNA Damage Checkpoint Chromosome Organization Cellular Response To Stress Meiotic Nuclear Division Regulation Of Mitotic Recombination Telomere Maintenance Telomere Maintenance Via Telomerase DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Mitotic G2 DNA Damage Checkpoint Cell Cycle Process DNA Metabolic Process Mitotic Cell Cycle Process DNA Topological Change RNA-dependent DNA Replication Organelle Organization Double-strand Break Repair Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Kinase Activity Mitotic Cell Cycle Checkpoint Telomere Maintenance Via Telomere Lengthening Cellular Response To DNA Damage Stimulus Response To Stress Mitotic Cytokinesis Reciprocal Meiotic Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation Cell Cycle Checkpoint DNA Recombination Positive Regulation Of Transferase Activity Reproduction DNA Repair Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of DNA Recombination Cellular Nitrogen Compound Metabolic Process Activation Of APC-Cdc20 Complex Activity Transcription, RNA-templated Glycine Betaine Biosynthetic Process From Choline Adherens Junction Maintenance Positive Regulation Of Cellular Metabolic Process Cell Proliferation
Tagcloud ?		aa additive alleles allelic altering blm bloom carriers carrying consistency estimates frequencies ga increment myelodysplatic penetrance pronounced recombination rmi1 rs12945597 rs1563634 rs2532105 rs401549 snps spouses tagged tagsnps tt variant
Tagcloud (Difference) ?		aa additive alleles allelic altering blm bloom carriers carrying consistency estimates frequencies ga increment myelodysplatic penetrance pronounced recombination rmi1 rs12945597 rs1563634 rs2532105 rs401549 snps spouses tagged tagsnps tt variant
Tagcloud (Intersection) ?