TOP3A and BLM

Number of citations of the paper that reports this interaction (PMID 10734115)
116

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		TOP3A	BLM
Gene Name		topoisomerase (DNA) III alpha	Bloom syndrome, RecQ helicase-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Chromosome PML Body	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Male Germ Cell Nucleus Nucleus Replication Fork Nucleolus Cytoplasm Nuclear Matrix PML Body Pronucleus
	Molecular Function	DNA Binding DNA Topoisomerase Type I Activity Protein Binding Zinc Ion Binding	Bubble DNA Binding P53 Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Four-way Junction Helicase Activity ATPase Activity Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding
	Biological Process	DNA Topological Change Meiotic Nuclear Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Strand Renaturation DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To X-ray Replication Fork Processing DNA Duplex Unwinding Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Recombination Negative Regulation Of Mitotic Recombination Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Replication Fork Protection Regulation Of Binding Protein Oligomerization Negative Regulation Of Cell Division Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: BLM RECQL5	33 interactors: ATM ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 FANCD2 FEN1 MCRS1 MIB1 MLH1 MX1 PSMD3 RAD51 RAD51D RNF8 RPA1 SMC1A SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TOPBP1 TP53 TP53BP1 TRIM49 UBE2I UPF2 WRN
Entrez ID		7156	641
HPRD ID		03145	05211
Ensembl ID		ENSG00000177302	ENSG00000197299
Uniprot IDs		B4DK80 B4DSJ0 Q13472	P54132
PDB IDs			2KV2 2RRD
Enriched GO Terms of Interacting Partners?		DNA Duplex Unwinding DNA Geometric Change DNA Recombination DNA Replication DNA Conformation Change Cellular Response To Camptothecin Cellular Response To Hydroxyurea Response To Camptothecin Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Negative Regulation Of Thymocyte Apoptotic Process Replication Fork Protection DNA Repair DNA Double-strand Break Processing Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Strand Renaturation Positive Regulation Of Alpha-beta T Cell Proliferation Cellular Response To DNA Damage Stimulus Replication Fork Processing Mitotic G2 DNA Damage Checkpoint Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Thymocyte Apoptotic Process Negative Regulation Of DNA-templated Transcription, Elongation Chromosome Separation Chromosome Organization Negative Regulation Of DNA Recombination Cell Cycle Process DNA Metabolic Process Negative Regulation Of T Cell Apoptotic Process Response To X-ray G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Alkaloid Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of T Cell Apoptotic Process Negative Regulation Of DNA Replication Cellular Response To Stress Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Leukocyte Apoptotic Process Cellular Response To Ionizing Radiation Alpha-beta T Cell Differentiation Regulation Of Lymphocyte Apoptotic Process Regulation Of DNA Recombination Alpha-beta T Cell Activation Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Division	Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Repair Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Recombination Cell Cycle Response To Stress Cell Cycle Process Organelle Organization Response To Radiation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Aging Telomere Maintenance Nitrogen Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of DNA Metabolic Process Meiotic Nuclear Division Meiotic Cell Cycle Cell Cycle Checkpoint Response To Abiotic Stimulus Replicative Senescence Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Cellular Response To Ionizing Radiation Regulation Of DNA Replication Response To UV Cellular Response To Radiation Mitotic Cell Cycle Protein Sumoylation Metabolic Process DNA Damage Checkpoint DNA Conformation Change Response To Stimulus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Aging Regulation Of Cell Cycle Process
Tagcloud ?		aa additive alleles allelic altering blm bloom carriers carrying consistency estimates frequencies ga increment myelodysplatic penetrance pronounced recombination rmi1 rs12945597 rs1563634 rs2532105 rs401549 snps spouses tagged tagsnps tt variant	bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol
Tagcloud (Difference) ?		aa additive alleles allelic altering bloom carriers carrying consistency estimates frequencies ga increment myelodysplatic penetrance pronounced recombination rmi1 rs12945597 rs1563634 rs2532105 rs401549 snps spouses tagged tagsnps tt variant	bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol
Tagcloud (Intersection) ?		blm