TOP3A

Gene Name		topoisomerase (DNA) III alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Chromosome PML Body
	Molecular Function	DNA Binding DNA Topoisomerase Type I Activity Protein Binding Zinc Ion Binding
	Biological Process	DNA Topological Change Meiotic Nuclear Division
Pathways		Meiotic recombination
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: BLM RECQL5
Entrez ID		7156
HPRD ID		03145
Ensembl ID		ENSG00000177302
Uniprot IDs		B4DK80 B4DSJ0 Q13472
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Duplex Unwinding DNA Geometric Change DNA Recombination DNA Replication DNA Conformation Change Cellular Response To Camptothecin Cellular Response To Hydroxyurea Response To Camptothecin Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Negative Regulation Of Thymocyte Apoptotic Process Replication Fork Protection DNA Repair DNA Double-strand Break Processing Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Strand Renaturation Positive Regulation Of Alpha-beta T Cell Proliferation Cellular Response To DNA Damage Stimulus Replication Fork Processing Mitotic G2 DNA Damage Checkpoint Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Thymocyte Apoptotic Process Negative Regulation Of DNA-templated Transcription, Elongation Chromosome Separation Chromosome Organization Negative Regulation Of DNA Recombination Cell Cycle Process DNA Metabolic Process Negative Regulation Of T Cell Apoptotic Process Response To X-ray G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Alkaloid Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of T Cell Apoptotic Process Negative Regulation Of DNA Replication Cellular Response To Stress Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Leukocyte Apoptotic Process Cellular Response To Ionizing Radiation Alpha-beta T Cell Differentiation Regulation Of Lymphocyte Apoptotic Process Regulation Of DNA Recombination Alpha-beta T Cell Activation Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Division
Tagcloud ?		aa additive alleles allelic altering blm bloom carriers carrying consistency estimates frequencies ga increment myelodysplatic penetrance pronounced recombination rmi1 rs12945597 rs1563634 rs2532105 rs401549 snps spouses tagged tagsnps tt variant