ACTR8 and BMPR2

Number of citations of the paper that reports this interaction (PubMedID 15188402)
0

Data Source:
HPRD (in vitro)

		ACTR8	BMPR2
Description		actin related protein 8	bone morphogenetic protein receptor type 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Centrosome Ino80 Complex	Extracellular Space Nucleoplasm Plasma Membrane Caveola Clathrin-coated Pit Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Membrane Apical Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Organelle Receptor Complex Cell Body
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Embryonic Development Regulation Of DNA Metabolic Process Cell Division Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Regulation Of Cell Growth Blood Vessel Development Osteoblast Differentiation Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Tissue Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Lung Blood Pressure Cell Differentiation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Limb Development Endochondral Bone Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lung Vasculature Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Regulation Of Multicellular Organismal Development
Pathways		UCH proteinases DNA Damage Recognition in GG-NER	Signaling by BMP
Drugs			Dibotermin alfa Fostamatinib
Diseases
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) PR interval ( 32439900) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32154731 32203549) Urate levels ( 23263486)
Interacting Genes		2 interacting genes: BMPR2 HUNK	53 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRIPTO CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBA INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		93973	659
HPRD ID		09792	02880
Ensembl ID		ENSG00000113812	ENSG00000204217
Uniprot IDs		Q9H981	Q13873
PDB IDs		4FO0	2HLQ 3G2F 6UNP 7PPA 7PPB 7PPC 7U5O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Aortic Valve Development Protein Kinase Activity Protein Serine/threonine Kinase Activity Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Endochondral Bone Morphogenesis Transforming Growth Factor Beta Receptor Activity Semi-lunar Valve Development Mitral Valve Morphogenesis Maternal Placenta Development Lung Vasculature Development Kinase Activity Pharyngeal Arch Artery Morphogenesis Endothelial Cell Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Negative Regulation Of Vasoconstriction Endocardial Cushion Development Lymphangiogenesis Regulation Of Axon Extension Involved In Axon Guidance Retina Vasculature Development In Camera-type Eye Atrial Septum Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis Atrioventricular Valve Morphogenesis BMP Binding Negative Regulation Of Systemic Arterial Blood Pressure Heart Valve Development Chondrocyte Development Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Maternal Process Involved In Female Pregnancy Bone Morphogenesis Organelle Endothelial Cell Proliferation Positive Regulation Of Axon Extension Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Protein Tyrosine Kinase Binding Positive Regulation Of Bone Mineralization	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Osteoblast Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Multicellular Organismal Development Heart Development Cytokine Activity Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Ossification Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Developmental Process Cartilage Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Osteoblast Differentiation Regulation Of Developmental Process Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Bone Mineralization SMAD Binding Cell Differentiation Regulation Of Chondrocyte Differentiation Animal Organ Development Enzyme Activator Complex Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endocardial Cushion Formation BMP Receptor Binding Cellular Developmental Process Regulation Of Growth Protein Kinase Activity
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