CADPS2 and UBE2N

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		CADPS2	UBE2N
Gene Name		Ca++-dependent secretion activator 2	ubiquitin-conjugating enzyme E2N
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Junction Cytoplasmic Vesicle Membrane Presynaptic Membrane Postsynaptic Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol UBC13-MMS2 Complex UBC13-UEV1A Complex Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Lipid Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Poly(A) RNA Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Response To Starvation Protein Transport Synaptic Vesicle Priming Positive Regulation Of Exocytosis	Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA Repair Postreplication Repair Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Histone Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Histone Modification Regulation Of Histone Ubiquitination Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination
Pathways			Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Class I MHC mediated antigen processing & presentation IRAK1 recruits IKK complex Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Antiviral mechanism by IFN-stimulated genes Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System
Drugs
Diseases
GWAS		Brain structure ( 20171287)	Height ( 18391951)
Protein-Protein Interactions		14 interactors: BDNF BZRAP1 DMD DRD2 MEGF10 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U UBE2W	87 interactors: AMFR ARIH2 AURKA BARD1 BCL10 BFAR BIRC3 BIRC8 BRCA1 CADPS2 CHFR CHUK CNOT4 DTX1 DZIP3 F12 HLTF HSP90AA1 LRSAM1 MALT1 MARCH5 MARCH7 MIB1 MIB2 MID1 MKRN3 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PARK2 PELI1 PELI3 PJA2 RBCK1 RC3H2 RFWD3 RIPK1 RNF103 RNF11 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF152 RNF165 RNF167 RNF182 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SLC2A4 STUB1 TMEM189 TMEM189-UBE2V1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TRIM17 TRIM25 TRIM27 TRIM28 TRIM33 TRIM39 TRIM5 TRIM50 TRIM72 UBB UBC UBE2V1 UBE2V2 XIAP ZNRF1 ZNRF2 ZNRF3 ZNRF4
Entrez ID		93664	7334
HPRD ID		12996	04725
Ensembl ID		ENSG00000081803
Uniprot IDs		B7ZM57 Q86UW7	P61088
PDB IDs			1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4EPO 4IP3
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor Signaling Pathway Response To Hypoxia Protein K63-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Histone Ubiquitination Activation Of Innate Immune Response Protein Monoubiquitination Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Acid Secretion TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Regulation Of Innate Immune Response Positive Regulation Of Ligase Activity Cellular Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Catabolic Process Cellular Response To Oxygen Levels Response To Auditory Stimulus Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Ubiquitination Glutamate Secretion Positive Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Cellular Response To Stress Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Protein Metabolic Process Mitotic Spindle Assembly Checkpoint	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K63-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Ubiquitination Metabolic Process Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Activation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Proteolysis Regulation Of Signaling Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Innate Immune Response Innate Immune Response Catabolic Process Immune Response Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cell Death
Tagcloud ?		alteration alterations arf frequently gain genomic hot ink4a instability mutants mutation mutations obvious p16 p53 piwil4 point prepared reason restraining resulting saos specificity spot suppresses suppressor transcriptional trim9 tumors	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2q1 ube2z ubiquitin ubiquitination
Tagcloud (Difference) ?		alteration alterations arf frequently gain genomic hot ink4a instability mutants mutation mutations obvious p16 p53 piwil4 point prepared reason restraining resulting saos specificity spot suppresses suppressor transcriptional trim9 tumors	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2q1 ube2z ubiquitin ubiquitination
Tagcloud (Intersection) ?