CADPS2 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CADPS2	TTC3
Description		calcium dependent secretion activator 2	tetratricopeptide repeat domain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Lipid Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Exocytosis Cellular Response To Starvation Protein Transport Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Hematopoietic Stem Cell Homeostasis Dense Core Granule Exocytosis	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Adult body size ( 32376654) Attention deficit hyperactivity disorder ( 30478444 32279069) Brain structure ( 20171287) General risk tolerance (MTAG) ( 30643258) Menarche (age at onset) ( 25231870) Number of sexual partners ( 30643258) Serum sulfate level ( 27412988) Smoking status (ever vs never smokers) ( 30643258) Waist circumference ( 28552196)	Eye color traits ( 20463881)
Interacting Genes		18 interacting genes: BDNF DMD DRD2 MEGF10 SRPK2 TMEM132D TSPOAP1 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U UBE2W WDR4	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		93664	7267
HPRD ID		12996	03773
Ensembl ID		ENSG00000081803	ENSG00000182670
Uniprot IDs		B7ZM57 Q86UW7 X5D2D9 X5D7B2 X5D8X0 X5DNG0	H7BZ57 P53804
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification Process Transferase Activity ATP Binding Macromolecule Catabolic Process Proteolysis Nucleotide Binding Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination TOR Signaling Proteasomal Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Protein K6-linked Ubiquitination Protein Catabolic Process Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Regulation Of TOR Signaling Macromolecule Metabolic Process DNA Damage Response DNA Repair Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Lateral Plasma Membrane Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cellular Response To Nutrient Levels Protein Autoubiquitination Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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