SLIT2 and ROBO2

Number of citations of the paper that reports this interaction (PubMedID 10102268)
0

Data Source:
HPRD (in vitro)

		SLIT2	ROBO2
Description		slit guidance ligand 2	roundabout guidance receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Membrane Extracellular Exosome	Plasma Membrane Cell Surface Membrane Axolemma Extracellular Exosome
	Molecular Function	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Roundabout Binding	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Ureteric Bud Development Kidney Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Chemotaxis Nervous System Development Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Olfactory Bulb Development Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Telencephalon Cell Migration Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Regulation Of Cellular Component Size Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Ventricular Septum Morphogenesis Epithelial Tube Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Circulatory System Development Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus	Metanephros Development Ureteric Bud Development Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Tube Development Aorta Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Cell-cell Adhesion
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs Formation of the ureteric bud	Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud
Drugs
Diseases			Vesicoureteral reflux
GWAS		Adiponectin levels x Mediterranean diet adherence interaction ( 33562295) Adult body size ( 32376654) Body mass index ( 31453325) Body mass index variance ( 31453325) Early spontaneous preterm birth ( 31194736) Echocardiographic traits ( 17903301) Gestational age at birth (child effect) ( 31194736) HDL cholesterol levels in HIV infection ( 33109212) Pars orbitalis volume ( 31530798) QRS duration ( 27659466) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Bell's palsy ( 33602968) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		7 interacting genes: GPC1 HOXA1 OGT ROBO1 ROBO2 UBC USP7	18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4
Entrez ID		9353	6092
HPRD ID		04776	11895
Ensembl ID		ENSG00000145147	ENSG00000185008
Uniprot IDs		O94813	A0A8Q3SIU0 A0A8Q3SIW8 A0A8Q3WLE3 A0A994J7I9 F8W703 H7C4J7 H7C4U9 H7C4W9 Q9HCK4
PDB IDs		2V70 2V9S 2V9T 2WFH	1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?		Artery Development Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Axon Choice Point Recognition Heart Induction Regulation Of Heart Morphogenesis Axon Guidance Receptor Activity Regulation Of Animal Organ Morphogenesis Endocardial Cushion Formation Pulmonary Valve Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Blood Vessel Development Organ Induction Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Translation Outflow Tract Septum Morphogenesis Regulation Of Animal Organ Formation Developmental Induction Aorta Development Aortic Valve Morphogenesis Metanephros Development Ventricular Septum Morphogenesis Positive Regulation Of Notch Signaling Pathway Tube Development Neuron Recognition Mesonephric Epithelium Development Mesonephric Tubule Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chemotaxis Positive Regulation Of Macromolecule Biosynthetic Process Semicircular Canal Formation Positive Regulation Of Metabolic Process Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Thyroid-stimulating Hormone Secretion Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Inner Ear Development Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Gene Expression Positive Regulation Of Developmental Process Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Relaxation Of Cardiac Muscle	Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Regulation Of Negative Chemotaxis Negative Chemotaxis Roundabout Binding Response To Cortisol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Cytokine-mediated Signaling Pathway Cardiac Septum Morphogenesis Axon Extension Involved In Axon Guidance Neuron Projection Guidance Axon Guidance Endothelial Cell Migration Pulmonary Valve Morphogenesis Chemotaxis Locomotion Regulation Of G Protein-coupled Receptor Signaling Pathway Apoptotic Process Involved In Development Regulation Of Macroautophagy Positive Regulation Of Secretion Of Lysosomal Enzymes Histone H2AS1 Kinase Activity Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Axon Extension Signal Transduction Negative Regulation Of Chemotaxis Transport Vesicle Membrane Nuclear Receptor Activity Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Histone H3S28 Kinase Activity Negative Regulation Of Retinal Ganglion Cell Axon Guidance Aldehyde Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity Nuclear Proteasome Complex Protein Localization To Secretory Granule Negative Regulation Of Negative Chemotaxis Positive Regulation Of Axonogenesis
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