ROBO2 and SLIT2

Number of citations of the paper that reports this interaction (PMID 10102268)
168

Data Source:
HPRD (in vitro)

		ROBO2	SLIT2
Gene Name		roundabout, axon guidance receptor, homolog 2 (Drosophila)	slit homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Cell Surface Integral Component Of Membrane Axolemma Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Chemorepellent Activity Roundabout Binding
	Biological Process	Metanephros Development Ureteric Bud Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Apoptotic Process Involved In Luteolysis	Metanephros Development Ureteric Bud Development In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Smooth Muscle Cell Migration Single Organismal Cell-cell Adhesion Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Dorsal/ventral Axon Guidance Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Mammary Duct Terminal End Bud Growth Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways		Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)	Echocardiographic traits ( 17903301)
Protein-Protein Interactions		16 interactors: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4	4 interactors: GPC1 ROBO1 ROBO2 UBC
Entrez ID		6092	9353
HPRD ID		11895	04776
Ensembl ID		ENSG00000185008	ENSG00000145147
Uniprot IDs		Q9HCK4	O94813
PDB IDs		1UEM 1UJT 2EDJ	2V70 2V9S 2V9T 2WFH
Enriched GO Terms of Interacting Partners?		Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Regulation Of Cytokine-mediated Signaling Pathway Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Regulation Of Negative Chemotaxis Luteolysis Response To Cortisol Sprouting Angiogenesis Mammary Duct Terminal End Bud Growth Signal Transduction Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Response To Stimulus Olfactory Bulb Interneuron Development Axon Extension Involved In Axon Guidance Signaling Endothelial Cell Migration Cell Communication Chemotaxis Cerebral Cortex Tangential Migration Positive Regulation Of Cell Death Epithelial Cell Migration Epithelium Migration Olfactory Bulb Interneuron Differentiation Response To External Stimulus Axon Guidance Developmental Growth Involved In Morphogenesis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Chemotaxis Response To Stimulus Apoptotic Process Involved In Development Ameboidal-type Cell Migration Response To Steroid Hormone Regulation Of Cellular Process Regulation Of Protein Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Apoptotic Process Axonogenesis Olfactory Bulb Development Axon Extension Programmed Cell Death Cell Surface Receptor Signaling Pathway Olfactory Lobe Development Cell Death	Negative Regulation Of Negative Chemotaxis Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Axon Choice Point Recognition Olfactory Bulb Interneuron Development Olfactory Bulb Interneuron Differentiation Negative Regulation Of Chemotaxis Forebrain Neuron Development Neuron Recognition Axon Guidance Olfactory Bulb Development Olfactory Lobe Development Forebrain Neuron Differentiation Axonogenesis Axon Development Positive Regulation Of Axonogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Forebrain Generation Of Neurons Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cellular Response To Growth Factor Stimulus Central Nervous System Neuron Development Neuron Projection Development Cell Recognition Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Regulation Of Chemotaxis Neuron Development Regulation Of Axonogenesis Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Programmed Cell Death Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Heparan Sulfate Proteoglycan Catabolic Process Cell Death Death Cell Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Negative Regulation Of Signal Transduction Neuron Differentiation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Projection Organization Pathogenesis Apoptotic Process Involved In Luteolysis Proteoglycan Catabolic Process Roundabout Signaling Pathway Negative Regulation Of Signaling
Tagcloud ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing	146a 196a 23b 34a 7c condylomata feature head hpv hpv11 hpv16 hpv6 hr hypermethylation immunohistochemical immunostaining ink4a intronic ki let mir mirnas neck overexpressed p16 panel penile pscc psccs
Tagcloud (Difference) ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing	146a 196a 23b 34a 7c condylomata feature head hpv hpv11 hpv16 hpv6 hr hypermethylation immunohistochemical immunostaining ink4a intronic ki let mir mirnas neck overexpressed p16 panel penile pscc psccs
Tagcloud (Intersection) ?