ROBO2 and NR1H2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ROBO2	NR1H2
Description		roundabout guidance receptor 2	nuclear receptor subfamily 1 group H member 2
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axolemma Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Apolipoprotein A-I Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding ATPase Binding
	Biological Process	Metanephros Development Ureteric Bud Development Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Tube Development Aorta Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Response To Nutrient Levels Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis MRNA Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of MiRNA Transcription Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud	PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs			GW-3965 Benzenesulfinic acid TO-901317 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein
Diseases		Vesicoureteral reflux
GWAS		Bell's palsy ( 33602968) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4	52 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PPARA PPARD PPARG PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A TTC3 UBE2D1 UBE2I VDR VIM YY1 ZXDC
Entrez ID		6092	7376
HPRD ID		11895	02660
Ensembl ID		ENSG00000185008	ENSG00000131408
Uniprot IDs		A0A8Q3SIU0 A0A8Q3SIW8 A0A8Q3WLE3 A0A994J7I9 F8W703 H7C4J7 H7C4U9 H7C4W9 Q9HCK4	F1D8P7 P55055
PDB IDs		1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA	1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6K9G 6K9H 6K9M 6S4N 6S4T 6S4U 6S5K
Enriched GO Terms of Interacting Partners?		Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Regulation Of Negative Chemotaxis Negative Chemotaxis Roundabout Binding Response To Cortisol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Cytokine-mediated Signaling Pathway Cardiac Septum Morphogenesis Axon Extension Involved In Axon Guidance Neuron Projection Guidance Axon Guidance Endothelial Cell Migration Pulmonary Valve Morphogenesis Chemotaxis Locomotion Regulation Of G Protein-coupled Receptor Signaling Pathway Apoptotic Process Involved In Development Regulation Of Macroautophagy Positive Regulation Of Secretion Of Lysosomal Enzymes Histone H2AS1 Kinase Activity Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Axon Extension Signal Transduction Negative Regulation Of Chemotaxis Transport Vesicle Membrane Nuclear Receptor Activity Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Histone H3S28 Kinase Activity Negative Regulation Of Retinal Ganglion Cell Axon Guidance Aldehyde Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity Nuclear Proteasome Complex Protein Localization To Secretory Granule Negative Regulation Of Negative Chemotaxis Positive Regulation Of Axonogenesis	Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor Binding Chromatin Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Response To Nutrient Levels Response To Lipid Nuclear Retinoic Acid Receptor Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Retinoic Acid-responsive Element Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process
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