ROBO2 and OLFM2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ROBO2	OLFM2
Gene Name		roundabout, axon guidance receptor, homolog 2 (Drosophila)	olfactomedin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Surface Integral Component Of Membrane Axolemma Extracellular Vesicular Exosome	Extracellular Region Cell Junction Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Synapse
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Metanephros Development Ureteric Bud Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Apoptotic Process Involved In Luteolysis	Protein Secretion
Pathways		Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)	Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		16 interactors: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4	11 interactors: BLOC1S6 EIF1 FANCF GNB5 KRTAP10-3 NBAS PKM ROBO2 RPS6 SRSF5 ST13
Entrez ID		6092	93145
HPRD ID		11895	10127
Ensembl ID		ENSG00000185008	ENSG00000105088
Uniprot IDs		Q9HCK4	K7EIS8 O95897
PDB IDs		1UEM 1UJT 2EDJ
Enriched GO Terms of Interacting Partners?		Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Regulation Of Cytokine-mediated Signaling Pathway Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Regulation Of Negative Chemotaxis Luteolysis Response To Cortisol Sprouting Angiogenesis Mammary Duct Terminal End Bud Growth Signal Transduction Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Response To Stimulus Olfactory Bulb Interneuron Development Axon Extension Involved In Axon Guidance Signaling Endothelial Cell Migration Cell Communication Chemotaxis Cerebral Cortex Tangential Migration Positive Regulation Of Cell Death Epithelial Cell Migration Epithelium Migration Olfactory Bulb Interneuron Differentiation Response To External Stimulus Axon Guidance Developmental Growth Involved In Morphogenesis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Chemotaxis Response To Stimulus Apoptotic Process Involved In Development Ameboidal-type Cell Migration Response To Steroid Hormone Regulation Of Cellular Process Regulation Of Protein Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Apoptotic Process Axonogenesis Olfactory Bulb Development Axon Extension Programmed Cell Death Cell Surface Receptor Signaling Pathway Olfactory Lobe Development Cell Death	Ovulation Cycle Process Negative Regulation Of Negative Chemotaxis Female Gonad Development Reproductive Structure Development Reproductive System Development Ovulation Cycle Development Of Primary Female Sexual Characteristics MRNA Metabolic Process Apoptotic Process Involved In Luteolysis Negative Regulation Of Protein Refolding Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Negative Chemotaxis Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Axon Midline Choice Point Recognition Chaperone Cofactor-dependent Protein Refolding Luteolysis Ribonucleoprotein Complex Assembly Negative Regulation Of Voltage-gated Calcium Channel Activity Oogenesis Stage Activation-induced Cell Death Of T Cells Secretion Of Lysosomal Enzymes Intracellular Transport Cytoplasmic Transport RNA Catabolic Process Axon Choice Point Recognition Developmental Process Involved In Reproduction Pigment Granule Maturation Synaptic Vesicle Docking Endosome To Melanosome Transport Multicellular Organismal Reproductive Process Olfactory Bulb Interneuron Development T Cell Proliferation Involved In Immune Response Gonad Development Translational Initiation Development Of Primary Sexual Characteristics Cellular Pigment Accumulation Multicellular Organism Reproduction Ribosomal Small Subunit Assembly Dosage Compensation By Inactivation Of X Chromosome Golgi Vesicle Transport Dosage Compensation Positive Regulation Of Pigment Cell Differentiation
Tagcloud ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?