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SLIT2
Description
slit guidance ligand 2
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Cell Surface
Membrane
Extracellular Exosome
Molecular Function
GTPase Inhibitor Activity
Calcium Ion Binding
Protein Binding
Heparin Binding
Identical Protein Binding
Protein Homodimerization Activity
Laminin-1 Binding
Proteoglycan Binding
Roundabout Binding
Biological Process
Ureteric Bud Development
Kidney Development
Negative Regulation Of Protein Phosphorylation
Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Leukocyte Chemotaxis
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Chemotaxis
Nervous System Development
Axon Guidance
Motor Neuron Axon Guidance
Negative Regulation Of Lamellipodium Assembly
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Smooth Muscle Cell Migration
Olfactory Bulb Development
Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration
Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration
Corticospinal Neuron Axon Guidance Through Spinal Cord
Telencephalon Cell Migration
Cell Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Negative Regulation Of Actin Filament Polymerization
Retinal Ganglion Cell Axon Guidance
Regulation Of Cellular Component Size
Cellular Response To Hormone Stimulus
Roundabout Signaling Pathway
Positive Regulation Of Apoptotic Process
Negative Regulation Of Vascular Permeability
Branching Morphogenesis Of An Epithelial Tube
Axon Extension Involved In Axon Guidance
Regulation Of Neurogenesis
Regulation Of Axonogenesis
Positive Regulation Of Axonogenesis
Negative Chemotaxis
Induction Of Negative Chemotaxis
Negative Regulation Of Small GTPase Mediated Signal Transduction
Response To Cortisol
Ventricular Septum Morphogenesis
Epithelial Tube Morphogenesis
Apoptotic Process Involved In Luteolysis
Negative Regulation Of Chemokine-mediated Signaling Pathway
Cellular Response To Heparin
Negative Regulation Of Smooth Muscle Cell Chemotaxis
Negative Regulation Of Mononuclear Cell Migration
Circulatory System Development
Negative Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Monocyte Chemotaxis
Negative Regulation Of Retinal Ganglion Cell Axon Guidance
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways
Netrin-1 signaling
Signaling by ROBO receptors
Signaling by ROBO receptors
Activation of RAC1
Regulation of commissural axon pathfinding by SLIT and ROBO
Inactivation of CDC42 and RAC1
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
SLIT2:ROBO1 increases RHOA activity
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
Formation of the ureteric bud
Drugs
Diseases
GWAS
Adiponectin levels x Mediterranean diet adherence interaction (
33562295
)
Adult body size (
32376654
)
Body mass index (
31453325
)
Body mass index variance (
31453325
)
Early spontaneous preterm birth (
31194736
)
Echocardiographic traits (
17903301
)
Gestational age at birth (child effect) (
31194736
)
HDL cholesterol levels in HIV infection (
33109212
)
Pars orbitalis volume (
31530798
)
QRS duration (
27659466
)
Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) (
24847101
)
Serum metabolite concentrations in chronic kidney disease (
29545352
)
Novel Interacting Genes
5 novel interacting genes:
CSDE1
PAX8
PDE4B
SEL1L3
ZCCHC4
Interacting Genes
7 interacting genes:
GPC1
HOXA1
OGT
ROBO1
ROBO2
UBC
USP7
Entrez ID
9353
HPRD ID
04776
Ensembl ID
ENSG00000145147
Uniprot IDs
O94813
PDB IDs
2V70
2V9S
2V9T
2WFH
Enriched GO Terms of Interacting Partners
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Artery Development
Negative Regulation Of Negative Chemotaxis
Axon Midline Choice Point Recognition
Regulation Of Negative Chemotaxis
Axon Choice Point Recognition
Heart Induction
Regulation Of Heart Morphogenesis
Axon Guidance Receptor Activity
Regulation Of Animal Organ Morphogenesis
Endocardial Cushion Formation
Pulmonary Valve Morphogenesis
Anatomical Structure Formation Involved In Morphogenesis
Blood Vessel Development
Organ Induction
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Translation
Outflow Tract Septum Morphogenesis
Regulation Of Animal Organ Formation
Developmental Induction
Aorta Development
Aortic Valve Morphogenesis
Metanephros Development
Ventricular Septum Morphogenesis
Positive Regulation Of Notch Signaling Pathway
Tube Development
Neuron Recognition
Mesonephric Epithelium Development
Mesonephric Tubule Development
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Chemotaxis
Positive Regulation Of Macromolecule Biosynthetic Process
Semicircular Canal Formation
Positive Regulation Of Metabolic Process
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Heart Valve Morphogenesis
Regulation Of Thyroid-stimulating Hormone Secretion
Regulation Of Gluconeogenesis
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
Inner Ear Development
Negative Regulation Of Multicellular Organismal Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
TORC1 Signaling
Positive Regulation Of Gene Expression
Positive Regulation Of Developmental Process
Abducens Nerve Formation
Optokinetic Behavior
Negative Regulation Of Relaxation Of Cardiac Muscle
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