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SLIT2
Gene Name
slit homolog 2 (Drosophila)
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Plasma Membrane
Cell Surface
Membrane
Extracellular Vesicular Exosome
Molecular Function
GTPase Inhibitor Activity
Calcium Ion Binding
Protein Binding
Heparin Binding
Identical Protein Binding
Protein Homodimerization Activity
Laminin-1 Binding
Proteoglycan Binding
Chemorepellent Activity
Roundabout Binding
Biological Process
Metanephros Development
Ureteric Bud Development
In Utero Embryonic Development
Negative Regulation Of Protein Phosphorylation
Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Leukocyte Chemotaxis
Axon Guidance
Motor Neuron Axon Guidance
Negative Regulation Of Cell Proliferation
Negative Regulation Of Lamellipodium Assembly
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Negative Regulation Of Smooth Muscle Cell Migration
Single Organismal Cell-cell Adhesion
Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration
Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration
Corticospinal Neuron Axon Guidance Through Spinal Cord
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Negative Regulation Of Actin Filament Polymerization
Retinal Ganglion Cell Axon Guidance
Cellular Response To Hormone Stimulus
Dorsal/ventral Axon Guidance
Roundabout Signaling Pathway
Positive Regulation Of Apoptotic Process
Negative Regulation Of Catalytic Activity
Negative Regulation Of Vascular Permeability
Branching Morphogenesis Of An Epithelial Tube
Axon Extension Involved In Axon Guidance
Positive Regulation Of Axonogenesis
Negative Chemotaxis
Induction Of Negative Chemotaxis
Negative Regulation Of Small GTPase Mediated Signal Transduction
Response To Cortisol
Mammary Duct Terminal End Bud Growth
Apoptotic Process Involved In Luteolysis
Negative Regulation Of Chemokine-mediated Signaling Pathway
Cellular Response To Heparin
Negative Regulation Of Smooth Muscle Cell Chemotaxis
Negative Regulation Of Mononuclear Cell Migration
Negative Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Monocyte Chemotaxis
Negative Regulation Of Retinal Ganglion Cell Axon Guidance
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways
Inactivation of Cdc42 and Rac
Role of Abl in Robo-Slit signaling
Axon guidance
Activation of Rac
Regulation of Commissural axon pathfinding by Slit and Robo
Netrin-1 signaling
Signaling by Robo receptor
Drugs
Diseases
GWAS
Echocardiographic traits (
17903301
)
Protein-protein Interactions
4 interactors:
GPC1
ROBO1
ROBO2
UBC
Entrez ID
9353
HPRD ID
04776
Ensembl ID
ENSG00000145147
Uniprot IDs
O94813
PDB IDs
2V70
2V9S
2V9T
2WFH
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Negative Chemotaxis
Regulation Of Negative Chemotaxis
Axon Midline Choice Point Recognition
Axon Choice Point Recognition
Olfactory Bulb Interneuron Development
Olfactory Bulb Interneuron Differentiation
Negative Regulation Of Chemotaxis
Forebrain Neuron Development
Neuron Recognition
Axon Guidance
Olfactory Bulb Development
Olfactory Lobe Development
Forebrain Neuron Differentiation
Axonogenesis
Axon Development
Positive Regulation Of Axonogenesis
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Forebrain Generation Of Neurons
Neuron Projection Morphogenesis
Cell Morphogenesis Involved In Differentiation
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Central Nervous System Neuron Development
Neuron Projection Development
Cell Recognition
Cell Projection Morphogenesis
Positive Regulation Of Cell Differentiation
Cell Part Morphogenesis
Regulation Of Chemotaxis
Neuron Development
Regulation Of Axonogenesis
Apoptotic Process
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Programmed Cell Death
Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration
Heparan Sulfate Proteoglycan Catabolic Process
Cell Death
Death
Cell Morphogenesis
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Behavior
Negative Regulation Of Signal Transduction
Neuron Differentiation
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell Projection Organization
Pathogenesis
Apoptotic Process Involved In Luteolysis
Proteoglycan Catabolic Process
Roundabout Signaling Pathway
Negative Regulation Of Signaling
Tagcloud
?
146a
196a
23b
34a
7c
condylomata
feature
head
hpv
hpv11
hpv16
hpv6
hr
hypermethylation
immunohistochemical
immunostaining
ink4a
intronic
ki
let
mir
mirnas
neck
overexpressed
p16
panel
penile
pscc
psccs